Department of Family Medicine, Wonkwang University Hospital, Iksan 54538, Korea.
Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan 54538, Korea.
Int J Environ Res Public Health. 2021 Dec 13;18(24):13145. doi: 10.3390/ijerph182413145.
The aims of this study were as follows: to investigate the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and health-related quality of life (HRQoL), to evaluate whether stress perception and mental health among patients with MAFLD affect HRQoL, and to identify the underrated burden on MAFLD patients. Nationwide data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES V, 2010 to 2012) were used. MAFLD was defined by a fatty liver index (FLI) of ≥60, and the EuroQol-5D (EQ-5D) was used to assess HRQoL. Logistic regression analysis and odds ratios (ORs) were used to determine the associations of MAFLD with stress, mental health, and HRQoL. Previous suicidal impulse was not found to be significantly associated with HRQoL. The risk of MAFLD increased 1.265-fold with an increase in stress levels based on the stress perception rate (confidence index (CI): 1.046-1.530; < 0.05), while it increased 1.091-fold with a 1-point decrease in the EQ-5D score (CI: 1.019-1.169; < 0.05). HRQoL impairment and stress levels are associated with MAFLD. It is important to evaluate stress levels among MAFLD patients and implement stress management and HRQoL improvement strategies.
探讨代谢相关脂肪性肝病（MAFLD）与健康相关生活质量（HRQoL）之间的关联，评估 MAFLD 患者的压力感知和心理健康状况是否影响 HRQoL，以及确定 MAFLD 患者被低估的负担。本研究使用了来自第 5 次韩国国家健康和营养调查（KNHANES V，2010 年至 2012 年）的全国性数据。MAFLD 定义为脂肪性肝指数（FLI）≥60，使用欧洲五维健康量表（EQ-5D）评估 HRQoL。使用逻辑回归分析和比值比（OR）确定 MAFLD 与压力、心理健康和 HRQoL 的关联。先前的自杀冲动与 HRQoL 没有显著关联。基于压力感知率，MAFLD 的风险随着压力水平的增加而增加 1.265 倍（置信指数（CI）：1.046-1.530；<0.05），而随着 EQ-5D 评分降低 1 分，MAFLD 的风险增加 1.091 倍（CI：1.019-1.169；<0.05）。HRQoL 受损和压力水平与 MAFLD 相关。评估 MAFLD 患者的压力水平并实施压力管理和 HRQoL 改善策略非常重要。
