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全球动脉粥样硬化研究领域的表观遗传学趋势:文献计量学和可视化研究。

Global Trends in Atherosclerosis Research in the Epigenetics Field: Bibliometric and Visualization Studies.

机构信息

Laboratory Animal Center, Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

Int J Environ Res Public Health. 2021 Dec 13;18(24):13154. doi: 10.3390/ijerph182413154.

Abstract

Atherosclerosis is a pathological vascular state caused by the interaction of environmental and hereditary factors. Epigenetic modifications may be the bridge connecting environmental factors and genetic factors. A search for publications on the Web of Science database in the field of atherosclerosis related to epigenetics was conducted from the earliest mention to 31 December 2020. Data on total and annual publications, citations, impact factors, Hirsch (H)-index, citation times, most prolific authors, and frequently published journals were collected for quantitative and qualitative comparison. A total of 1848 publications related to epigenetics and atherosclerosis were found. The major contributing countries were the China (522, 28.23%), United States (485, 26.23%), and Germany (119, 6.44%). The greatest number of retrieved publications were published in the journal, "Arteriosclerosis, Thrombosis, and Vascular Biology" (62, 3.66%). The publication "Oxidative Stress and Diabetic Complications" was cited 2370 times. The most frequent keywords were "DNA methylation" and "LncRNA". Publications on epigenetic research in the atherosclerosis field have increased significantly every year, indicating that the study of epigenetic modifications plays an increasingly important role in understanding the pathology of atherosclerosis.

摘要

动脉粥样硬化是一种由环境和遗传因素相互作用引起的病理性血管状态。表观遗传修饰可能是连接环境因素和遗传因素的桥梁。在 Web of Science 数据库中对与动脉粥样硬化相关的表观遗传学进行了文献检索,检索时间从最早的报道到 2020 年 12 月 31 日。收集了总出版物和年度出版物、引文、影响因子、Hirsch (H)-指数、引文次数、最多产的作者和经常发表的期刊的数据,进行了定量和定性比较。共发现 1848 篇与动脉粥样硬化相关的表观遗传学文献。主要贡献国家是中国(522,28.23%)、美国(485,26.23%)和德国(119,6.44%)。检索到的出版物中,发表在《动脉硬化、血栓形成和血管生物学》(62,3.66%)上的最多。引用次数最多的出版物是《氧化应激与糖尿病并发症》(2370 次)。最常见的关键词是“DNA 甲基化”和“LncRNA”。动脉粥样硬化领域的表观遗传学研究每年都在显著增加,这表明对表观遗传修饰的研究在理解动脉粥样硬化病理学方面发挥着越来越重要的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d6f/8701235/318bf3f94700/ijerph-18-13154-g001.jpg

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