Uuskiula M M, Lamp K M, Martin S I
Kardiologiia. 1987 Feb;27(2):57-60.
Seventy-eight patients with acute myocardial infarction (MI) were examined in order to assess the place of immune response caused by myocardial necrosis in the clinical pattern of the disease. The extent of autosensitization was estimated on the basis of E-RFC inhibition and lymphotoxin production in lymphocyte cultures in the presence of myocardial antigen. Sensitized lymphocytes emerge in the blood during the second week in primary acute MI, and during the first day in repeated acute MI. Patients with marked autosensitization more frequently developed recurrent anginal attacks and cardiovascular insufficiency; they were the only ones to show Dressler's syndrome and fatal outcomes. A positive correlation between cell sensitization and elevated IgG was seen during the third week of the disease. Lymphotoxin production tended to be increased in patients with repeated acute MI and Dressler's syndrome.
为评估心肌坏死引发的免疫反应在急性心肌梗死（MI）临床症状中的作用，对78例急性心肌梗死患者进行了检查。基于心肌抗原存在时淋巴细胞培养中E - 玫瑰花结形成细胞（E - RFC）抑制和淋巴毒素产生情况来评估自身致敏程度。在原发性急性心肌梗死的第二周以及再次急性心肌梗死的第一天，血液中出现致敏淋巴细胞。自身致敏明显的患者更常出现复发性心绞痛发作和心血管功能不全；他们是唯一出现德雷斯勒综合征（Dressler's syndrome）和致命结局的患者。在疾病的第三周，观察到细胞致敏与IgG升高之间呈正相关。在再次急性心肌梗死和德雷斯勒综合征患者中，淋巴毒素产生往往增加。
