Department of Anatomical Pathology, SA Pathology at Flinders Medical Centre, Adelaide, SA 5042, Australia.
Department of Anatomical Pathology, Flinders University, Adelaide, SA 5042, Australia.
Int J Environ Res Public Health. 2021 Dec 17;18(24):13310. doi: 10.3390/ijerph182413310.
Malignant mesothelioma is a tumour of the serosal membranes, related to asbestos exposure. Median latency is in the order of 40 years in various registries, but small numbers of cases with shorter latencies have long been reported and often dismissed as unrelated to asbestos exposure. However, emerging data regarding the significance of inherited mutations leading to a predisposition to mesothelioma suggest that the causative effect of asbestos may be associated with shorter latencies in a subset of patients. Here, we describe a male patient with germline mutations in RAD51 and p53 who developed peritoneal mesothelioma 8.5 years after well-documented asbestos exposure and discuss the current literature on the subject. Mesothelioma in situ is now a WHO-accepted diagnosis, but preliminary data reveal a potential lead time of 5 or more years to invasive disease, and this is also a factor which may affect the recording of latency (and potentially survival) in the future.
恶性间皮瘤是一种发生于浆膜层的肿瘤，与石棉暴露有关。在不同的登记处，中位数潜伏期约为 40 年，但长期以来一直有少量潜伏期较短的病例报告，并经常被认为与石棉暴露无关。然而，关于导致间皮瘤易感性的遗传突变的重要数据表明，石棉的致病作用可能与一部分患者的潜伏期较短有关。在这里，我们描述了一例男性患者，他携带 RAD51 和 p53 的种系突变，在有记录的石棉暴露 8.5 年后发展为腹膜间皮瘤，并讨论了目前关于该主题的文献。间皮瘤原位是世界卫生组织（WHO）认可的诊断，但初步数据显示，侵袭性疾病的潜在前置时间为 5 年或更长，这也是未来可能影响潜伏期（和潜在生存）记录的一个因素。
