Bilger Andrea, Lambert Paul F
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI, 53705, USA.
Tumour Virus Res. 2025 Jan 2;19:200312. doi: 10.1016/j.tvr.2024.200312.
Human cancers are generally thought to develop over the course of decades. Such slow progression is well documented for a variety of cancers that we designate "slow-onset" cancers. "Rapid-onset" cancers, in contrast, can develop in a matter of months in humans or in as little as 9 days in mice. These cancers often develop under conditions that might be expected to accelerate cancer development: early development, immune deficiency, or viral infection. We will discuss rapid-onset cancers in the context of the "hallmarks of cancer" - properties cells must acquire in order to become malignant - focusing on how viruses are particularly well suited to causing rapid-onset cancer.
一般认为人类癌症的发展过程长达数十年。我们将这类进展缓慢的癌症称为“慢发性”癌症，已有大量文献证明了其进展的缓慢。相比之下，“快发性”癌症在人类身上可能在数月内形成，在小鼠身上甚至短短9天内就能形成。这些癌症往往在一些可能会加速癌症发展的条件下产生，比如早期发育、免疫缺陷或病毒感染。我们将在“癌症标志”的背景下讨论快发性癌症，即细胞要变成恶性细胞必须获得的特性，重点探讨病毒为何特别容易引发快发性癌症。
