Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City 11490, Taiwan.
Int J Environ Res Public Health. 2021 Dec 20;18(24):13416. doi: 10.3390/ijerph182413416.
Obstructive sleep apnea (OSA) has been reported to increase the risk of motor vehicle accidents. However, only few studies have investigated the effects of OSA on overall risk injury. The aim of study is to investigate whether OSA increases the risk of overall injury. The data were collected during 2000-2015 from Taiwan's National Health Insurance Research Database. A total of 8901 individuals diagnosed with OSA were inpatients, or outpatients at least three times were enrolled. Finally, 6915 participants with OSA were included as the study cohort. We matched the study cohort with a comparison cohort, at a ratio of 1:4. Cox proportional hazards regression was used to analyse the association between OSA and overall injury. Patients with OSA had 83.1% increased risk of overall injury, compared to non-OSA individuals [adjusted hazards ratio (HR) = 1.831, confidence interval (CI) = 1.674-2.020, < 0.001]. In the stratified age group, patients aged ≧65 years had the highest risk of injury (adjusted HR= 2.014; CI = 1.842-2.222, < 0.001). Patients with OSA were at a higher risk of falls, traffic injury, poisoning, suffocation, suicide, and abuse or homicide than non-OSA individuals, with falls and traffic injury as the leading causes of injuries. The data demonstrated that patients with OSA have a higher risk of overall injury. The study results can be a reference for developing injury prevention strategies in the future. The general population and clinicians should have more awareness regarding OSA and its negative effects on injury development.
阻塞性睡眠呼吸暂停（OSA）已被报道会增加机动车事故的风险。然而，只有少数研究调查了 OSA 对总体伤害风险的影响。本研究旨在调查 OSA 是否会增加总体伤害风险。该数据于 2000 年至 2015 年期间从台湾全民健康保险研究数据库中收集。共纳入了 8901 名 OSA 住院或至少三次门诊患者。最终，共有 6915 名 OSA 患者纳入研究队列。我们将研究队列与对照组进行了匹配，比例为 1:4。使用 Cox 比例风险回归分析 OSA 与总体伤害之间的关联。与非 OSA 个体相比，OSA 患者总体伤害的风险增加了 83.1%[校正风险比（HR）=1.831，95%置信区间（CI）=1.674-2.020， < 0.001]。在分层年龄组中，年龄≧65 岁的患者受伤风险最高（校正 HR=2.014；CI=1.842-2.222， < 0.001）。与非 OSA 个体相比，OSA 患者发生跌倒、交通伤害、中毒、窒息、自杀和虐待或他杀的风险更高，而跌倒和交通伤害是导致伤害的主要原因。数据表明，OSA 患者总体伤害风险更高。研究结果可为未来制定伤害预防策略提供参考。普通人群和临床医生应更加关注 OSA 及其对伤害发生的负面影响。
