Tantawy Rami Fatouh, Elsharkawy Ahmed S, Salman Samar S, Elfayomy Ahmed Elsayed, Bioumy Omneya E
Otorhinolaryngology Department, Faculty of Medicine, Benha University, Benha, 13511 Qalyubia Egypt.
Otorhinolology Department, Shebein Elkom Teatching Hospital, Menoufiya, 32512 Egypt.
Indian J Otolaryngol Head Neck Surg. 2025 Jan;77(1):318-324. doi: 10.1007/s12070-024-05178-6. Epub 2024 Nov 7.
The research was designed to predict the relationship between the apnea-hypopnea index (AHI) as the main indicator of severity of obstructive sleep apnea syndrome (OSAS), and lipid panel test results. A cross-sectional observational study was done on 90 patients with suspected sleep-related breathing disorders as assumed by polysomnography. Patients were categorized into three equal groups depending on AHI: mild degree (5-15 events/hour), moderate degree (15-30 events/hour), and severe degree (> 30 events/hour). All patients underwent a comprehensive medical history, PSG, and lipid panel tests, which included measurements of total cholesterol level, low-density lipoprotein (LDL) level, very low-density lipoprotein (VLDL) level, high-density lipoprotein (HDL) level, and triglycerides (TGs) level. Aclose relation was noted between degree of severity of OSA and lipid panel tests that in third group (Severe degree) exhibited significantly higher levels of triglycerides (212 ± 36 mg/dL), total cholesterol (180 ± 54 mg/dL), and LDL (178.1 ± 39.8 mg/dL) compared to those with moderate (TGs: 158 ± 57 mg/dL, total cholesterol: 151 ± 65 mg/dL, LDL: 153.2 ± 31.5 mg/dL) and mild OSA (TGs: 106 ± 37 mg/dL, total cholesterol: 85 ± 12 mg/dL, LDL: 87 ± 9.3 mg/dL), with P-values < 0.001. Conversely, significantly lower level of HDLin the severe OSA group (25.8 ± 3.6 mg/dL) compared to moderate (32.7 ± 4.2 mg/dL) and mild OSA groups (45.8 ± 9.2 mg/dL), with a -value < 0.001. so analysis of Multivariate linear regression unveiled that both moderate and severe OSA stood as independent predictors for elevated TC, TGs, and LDL levels, alongside diminished HDL levels, according to age, sex, and BMI. Oxygen desaturation due to OSA significantly impacts lipid metabolism, leading to dyslipidemia and increased cardiovascular risk.
该研究旨在预测作为阻塞性睡眠呼吸暂停低通气综合征（OSAS）严重程度主要指标的呼吸暂停低通气指数（AHI）与血脂检测结果之间的关系。对90例经多导睡眠监测怀疑患有睡眠相关呼吸障碍的患者进行了横断面观察性研究。根据AHI将患者分为三组，每组人数相等：轻度（5 - 15次/小时）、中度（15 - 30次/小时）和重度（>30次/小时）。所有患者均接受了全面的病史询问、多导睡眠监测和血脂检测，血脂检测包括总胆固醇水平、低密度脂蛋白（LDL）水平、极低密度脂蛋白（VLDL）水平、高密度脂蛋白（HDL）水平和甘油三酯（TGs）水平的测量。研究发现OSA严重程度与血脂检测之间存在密切关系，与中度（TGs：158±57mg/dL，总胆固醇：151±65mg/dL，LDL：153.2±31.5mg/dL）和轻度OSA（TGs：106±37mg/dL，总胆固醇：85±12mg/dL，LDL：87±9.3mg/dL）相比，第三组（重度）的甘油三酯（212±36mg/dL）、总胆固醇（180±54mg/dL）和LDL（178.1±39.8mg/dL）水平显著更高，P值<0.001。相反，与中度（32.7±4.2mg/dL）和轻度OSA组（45.8±9.2mg/dL）相比，重度OSA组的HDL水平显著更低（25.8±3.6mg/dL），P值<0.001。因此，多元线性回归分析表明，根据年龄、性别和体重指数，中度和重度OSA均是总胆固醇、甘油三酯和LDL水平升高以及HDL水平降低的独立预测因素。OSA导致的氧饱和度下降显著影响脂质代谢，导致血脂异常并增加心血管疾病风险。
