Wang Huiying, Chen Lin, Qian Jiawen, Chen Lin, Lan Meifang, Zhuang Jiajie, Jiang Xin, Shi Bin, Lin Lisong, Qiu Yu, Zheng Xiaoyan, Wang Jing, Liu Fengqiong, He Baochang, Chen Fa
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350004, China.
Wei Sheng Yan Jiu. 2021 Nov;50(6):944-951. doi: 10.19813/j.cnki.weishengyanjiu.2021.06.012.
To explore the association between hypertension and prognosis of oral cancer patients in non-smoking and non-drinking women.
From September 2010 to February 2019, 362 non-smoking and non-drinking female patients with pathologically confirmed oral cancer were recruited and followed up in the First Affiliated Hospital of Fujian Medical University. The patients were divided into hypertension group and non-hypertensive group, and the Kaplan-Meier method was performed to calculate the cumulative survival rate. The survival curve was tested by the log-rank method for differences between the two groups. Cox proportional regression model was utilized to explore the prognostic factors. 1∶1 propensity score matching was applied in order to verify the above findings. Stratified analysis was used to explore the prognosis of oral cancer treated by different method and fish intake between two groups respectively.
The Cox proportional hazards model showed that the risk of death of hypertension patients was 1.976 times than nonhypertensive patients(95%CI 1.003-3.890), the risk of death for patients with lymph node metastasis was 2.938 times than patients without metastasis(95%CI 1.318-6.551), the risk of death for patients underwent surgery combined with adjuvant therapy was 0.454 times than surgery alone(95%CI 0.236-0.875). After propensity score matching, the Cox proportional hazard model showed that the risk of death for patients with hypertension was 2.987 times than non-hypertensive patients(95%CI 1.050-8.497). The result of stratified analysis showed that the risk of death for non-hypertensive patients with surgery combined with adjuvant therapy was 0.233 times than patients with surgery alone(95%CI 0.085-0.643) and the risk of death in patients with hypertension who consumed fish ≥3 times/week was 0.020 times higher than that in women with oral cancer who consumed fish<3 times/week(95%CI 0.001-0.392).
Hypertension is an independent prognostic factor for oral cancer in non-smoking and non-drinking women. Non-hypertensive patients underwent surgery combined with adjuvant therapy can reduce the risk of death and the increase of fish intake can improve the prognosis of hypertensive female oral cancer patients.
探讨非吸烟、非饮酒女性口腔癌患者高血压与预后的关系。
选取2010年9月至2019年2月在福建医科大学附属第一医院收治的362例经病理确诊的非吸烟、非饮酒女性口腔癌患者进行随访。将患者分为高血压组和非高血压组，采用Kaplan-Meier法计算累积生存率，用log-rank检验比较两组生存曲线差异。采用Cox比例回归模型探讨预后影响因素，并应用1∶1倾向得分匹配法验证上述结果。分别采用分层分析探讨不同治疗方法及两组鱼类摄入量对口腔癌预后的影响。
Cox比例风险模型显示，高血压患者的死亡风险是非高血压患者的1.976倍（95%CI 1.003 - 3.890），有淋巴结转移患者的死亡风险是无转移患者的2.938倍（95%CI 1.318 - 6.551），手术联合辅助治疗患者的死亡风险是单纯手术患者的0.454倍（95%CI 0.236 - 0.875）。倾向得分匹配后，Cox比例风险模型显示，高血压患者的死亡风险是非高血压患者的2.987倍（95%CI 1.050 - 8.497）。分层分析结果显示，非高血压患者手术联合辅助治疗的死亡风险是单纯手术患者的0.233倍（95%CI 0.085 - 0.643），每周食用鱼类≥3次的高血压女性口腔癌患者的死亡风险是每周食用鱼类<3次的患者的0.020倍（95%CI 0.001 - 0.392）。
高血压是非吸烟、非饮酒女性口腔癌的独立预后因素。非高血压患者手术联合辅助治疗可降低死亡风险，增加鱼类摄入量可改善高血压女性口腔癌患者的预后。
