Perry T L, Hansen S, Jones K
Neurosci Lett. 1987 Feb 24;74(2):217-20. doi: 10.1016/0304-3940(87)90152-2.
Epidemiological surveys have repeatedly shown that idiopathic Parkinson's disease (PD) occurs less frequently in persons who have smoked cigarettes for many years than among age-matched non-smokers. Since PD might be caused by neurotoxins chemically similar to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we explored the possible protective effect of repeated exposure to cigarette smoke against MPTP neurotoxicity in the C57 black mouse. Mice given MPTP and exposed to cigarette smoke suffered just as great a depletion of striatal dopamine as did mice treated only with MPTP. We discovered also that different lots of C57 black mice obtained from a single supplier can have markedly different sensitivities to MPTP.
流行病学调查反复表明，多年吸烟的人患特发性帕金森病（PD）的频率低于年龄匹配的非吸烟者。由于PD可能由化学结构与1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）相似的神经毒素引起，我们研究了反复接触香烟烟雾对C57黑小鼠MPTP神经毒性可能的保护作用。给予MPTP并暴露于香烟烟雾中的小鼠，其纹状体多巴胺的耗竭程度与仅用MPTP处理的小鼠一样严重。我们还发现，从单一供应商处获得的不同批次的C57黑小鼠对MPTP的敏感性可能有显著差异。
