Sershen H, Mason M F, Reith M E, Hashim A, Lajtha A
Neuropharmacology. 1986 Aug;25(8):927-30. doi: 10.1016/0028-3908(86)90022-5.
Amphetamine has been shown to either potentiate or protect against MPTP neurotoxicity. The time course of changes in dopamine and its metabolites was examined after MPTP, amphetamine, or MPTP plus amphetamine administration. Results suggest that under conditions of granular depletion and release of dopamine by 10 mg/kg amphetamine, increased MPTP neurotoxicity occurs. Amphetamine injections at 2-5 mg/kg prevents the decline in dopamine possibly by blockade of the uptake of MPP+, rather than by an inhibition of monoamine oxidase.
已证实苯丙胺可增强或预防MPTP的神经毒性。在给予MPTP、苯丙胺或MPTP加苯丙胺后，检测了多巴胺及其代谢产物变化的时间进程。结果表明，在10mg/kg苯丙胺导致多巴胺颗粒耗竭和释放的情况下，MPTP神经毒性增加。2-5mg/kg的苯丙胺注射可能通过阻断MPP+的摄取而非抑制单胺氧化酶来防止多巴胺水平下降。
