Hirai N
Neurosci Res. 1987 Feb;4(3):167-84. doi: 10.1016/0168-0102(87)90010-1.
In the anaesthetized cat, lobules I and II of the cerebellar anterior lobe vermis were examined to determine their role in the vestibulospinal and neck-vestibulospinal reflexes with respect to: the somatotopic representation of afferent inputs from labyrinth, neck and tail; and the inhibitory influence on vestibulospinal tract (VST) neurones receiving vestibular and neck afferent inputs. After electrical stimulation of the vestibular nerve and of neck afferents, almost identical responses via mossy fibres were evoked in the lobules, with the prominent response in lobules I and IIa of Larsell. Stimulation of the nerve supplying the dorsal region of the tail induced primarily the mossy fibre response, but also the climbing fibre response, in lobule II. The most responsive areas to tail and neck afferent stimulation did not overlap each other. In the lateral vestibular nucleus, 163 antidromically identified VST neurones were recorded extra- or intracellularly. On the basis of the response pattern to contralateral neck afferent stimulation, they were classified into 3 groups: neurones with excitation (n = 45); neurones with inhibition (n = 71); and neurones with no modulation (n = 47). Stimulation of lobules I-IIa inhibited the activities of 44 VST neurones. Out of them, 41 neurones belonged to the first group. They made up 91% of the group. Twenty-nine of these neurones, i.e. neurones receiving excitatory inputs from the neck and inhibitory inputs from the lobules, received additional excitatory input from the labyrinth. Although lobules I-IIa may be regarded as neck area in the anterior lobe vermis from the viewpoint of sensory input, they did not exert inhibitory influence only exceptionally on vestibulocollic neurones, but predominantly on VST neurones sending their axons to lower thoracic or more caudal segments in the spinal cord. It is suggested from these results that lobules I-IIa have a close relationship with the neck reflex and/or interaction of neck and vestibulospinal reflexes being concerned with the postural adjustment of a rather wide area of the body.
在麻醉猫中，研究小脑前叶蚓部的I和II小叶，以确定它们在前庭脊髓反射和颈-前庭脊髓反射中的作用，具体涉及：来自迷路、颈部和尾部的传入输入的躯体定位表征；以及对接受前庭和颈部传入输入的前庭脊髓束（VST）神经元的抑制作用。在前庭神经和颈部传入神经受到电刺激后，小叶中通过苔藓纤维诱发了几乎相同的反应，其中Larsell的I和IIa小叶反应最为明显。刺激供应尾部背侧区域的神经主要在II小叶诱发苔藓纤维反应，但也诱发攀爬纤维反应。对尾部和颈部传入刺激反应最敏感的区域彼此不重叠。在外侧前庭核中，细胞外或细胞内记录了163个经逆向鉴定的VST神经元。根据对侧颈部传入刺激的反应模式，将它们分为3组：兴奋型神经元（n = 45）；抑制型神经元（n = 71）；无调制型神经元（n = 47）。刺激I-IIa小叶抑制了44个VST神经元的活动。其中，41个神经元属于第一组。它们占该组的91%。这些神经元中有29个，即接受来自颈部的兴奋性输入和来自小叶的抑制性输入的神经元，还接受来自迷路的额外兴奋性输入。尽管从感觉输入的角度来看，I-IIa小叶可被视为前叶蚓部的颈部区域，但它们并非仅偶尔对前庭颈神经元发挥抑制作用，而是主要对其轴突投射到脊髓下胸段或更尾端节段的VST神经元发挥抑制作用。从这些结果可以推测，I-IIa小叶与颈部反射和/或与身体相当大面积的姿势调整相关的颈部和前庭脊髓反射的相互作用密切相关。
