Shaaban Zahra, Khoradmehr Arezoo, Amiri-Yekta Amir, Nowzari Fariborz, Jafarzadeh Shirazi Mohammad Reza, Tamadon Amin
Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran.
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Genet Res (Camb). 2021 Dec 6;2021:7781823. doi: 10.1155/2021/7781823. eCollection 2021.
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women. PCOS is characterized by anovulation, hyperandrogenism, polycystic ovaries, insulin resistance, and obesity. Despite the finding that the genetic origin of PCOS is well demonstrated in previous twin and familial clustering studies, genes and factors that can exactly explain the PCOS pathophysiology are not known. In this review, we attempted to identify genes related to secretion and signaling of insulin aspects of PCOS and their physiological functions in order to explain the pathways that are regulated by these genes which can be a prominent function in PCOS predisposition. . For this purpose, published articles and reviews dealing with genetic evaluation of PCOS in women from peer-reviewed journals in PubMed and Google Scholar databases were included in this review. . The genomic investigations in women of different populations identified many candidate genes and loci that are associated with PCOS. The most important of them are , , , , , , , and . These are mainly associated with metabolic aspects of PCOS. . In this review, we proposed that each of these genes may interrupt specific physiological pathways by affecting them and contribute to PCOS initiation. It is clear that the role of genes involved in insulin secretion and signaling is more critical than other pathways.
多囊卵巢综合征（PCOS）是女性常见的一种内分泌疾病。PCOS的特征是无排卵、高雄激素血症、多囊卵巢、胰岛素抵抗和肥胖。尽管在先前的双胞胎和家族聚集性研究中已充分证明PCOS的遗传起源，但确切解释PCOS病理生理学的基因和因素尚不清楚。在本综述中，我们试图确定与PCOS胰岛素分泌和信号传导相关的基因及其生理功能，以解释这些基因所调控的途径，这些途径在PCOS易感性中可能起重要作用。为此，本综述纳入了来自PubMed和谷歌学术数据库中同行评审期刊上有关女性PCOS基因评估的已发表文章和综述。对不同人群女性的基因组研究确定了许多与PCOS相关的候选基因和基因座。其中最重要的是[此处未给出具体基因名称]、[此处未给出具体基因名称]、[此处未给出具体基因名称]、[此处未给出具体基因名称]、[此处未给出具体基因名称]、[此处未给出具体基因名称]、[此处未给出具体基因名称]和[此处未给出具体基因名称]。这些主要与PCOS的代谢方面相关。在本综述中，我们提出这些基因中的每一个可能通过影响特定生理途径而导致其中断，并促成PCOS的发病。显然，参与胰岛素分泌和信号传导的基因的作用比其他途径更为关键。
