School of Medicine, Guangxi University of Science and Technology, No.257 Liu-shi Road, Yufeng District, Liuzhou, 545005, China.
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, No.4 Dong-qing Road, Huaxi District, Guiyang, 550025, China.
J Ethnopharmacol. 2022 Aug 10;294:115275. doi: 10.1016/j.jep.2022.115275. Epub 2022 Apr 26.
Psoriasis is a chronic inflammatory dermatosis related to high morbidity and mortality. The incidence of psoriasis is increasing in recent decades. Some patients with psoriasis are anxious about the underlying side effects of synthetic drugs they are on. Therefore, they are eager to seek alternative and efficient therapy, such as Chinese herbal medicine (CHM). Researchers have found some CHM provides best source for the development of anti-psoriatic drugs because of their structural diversity and fewer adverse reactions. Some of CHM formulas or active constituents extracted from CHM have been rapidly developed into clinical drugs with good efficacy. At present, along with the CHM formulas, single CHM and its active components have been extensively accepted and utilized in the treatment of psoriasis, whose therapeutic mechanisms hitherto have not been thoroughly illustrated.
This review aimed to comprehensively summarize about the existing therapeutic mechanisms of CHM in the treatment of psoriasis and to provide a reference to develop future related studies in this field.
Relevant literatures about how CHM treated psoriasis were acquired from published scientific studies (including PubMed, CNKI, Web of Science, Baidu Scholar, The Plant List, Elsevier and SciFinder). All plants appearing in the review have been included in The Plant List or Medicinal Plant Names Services (MPNS).
In this review, we collect numerous literatures about how CHM treats psoriasis via immune cells, signaling pathways and disease-related mediators and systematically elucidates potential mechanisms from the point of the suppression of oxidative stress, the inhibition of abnormal abnormal proliferation and differentiation, the inhibition of immune responses, and the suppression of angiogenesis.
Psoriasis is considered as a complicated disease caused by interaction among various mechanisms. The CHM formulas, single CHM and its active components have considerable positive reports about the treatment of psoriasis, which brings hope for a promising future of CHM in the clinical therapy of psoriasis. In the paper, we have concluded that the existing therapeutic mechanisms of CHM in the treatment of psoriasis.
银屑病是一种慢性炎症性皮肤病，与高发病率和死亡率有关。近几十年来，银屑病的发病率一直在上升。一些银屑病患者对他们正在使用的合成药物的潜在副作用感到焦虑。因此，他们渴望寻求替代和有效的治疗方法，如中药（CHM）。研究人员发现，由于结构多样性和不良反应较少，一些 CHM 为开发抗银屑病药物提供了最佳来源。一些 CHM 配方或从 CHM 中提取的活性成分已迅速开发成疗效良好的临床药物。目前，随着 CHM 配方的出现，单一 CHM 及其活性成分已广泛应用于银屑病的治疗，其治疗机制迄今尚未得到充分阐明。
本综述旨在全面总结 CHM 治疗银屑病的现有治疗机制，为该领域未来相关研究提供参考。
从已发表的科学研究中（包括 PubMed、CNKI、Web of Science、百度学者、The Plant List、Elsevier 和 SciFinder）获取有关 CHM 治疗银屑病的相关文献。综述中出现的所有植物均包含在 The Plant List 或药用植物名称服务（MPNS）中。
在本综述中，我们收集了大量关于 CHM 通过免疫细胞、信号通路和与疾病相关的介质治疗银屑病的文献，并从抑制氧化应激、抑制异常增殖和分化、抑制免疫反应和抑制血管生成的角度系统地阐明了潜在的机制。
银屑病被认为是一种由多种机制相互作用引起的复杂疾病。CHM 配方、单一 CHM 及其活性成分在治疗银屑病方面有相当多的积极报道，为 CHM 在银屑病的临床治疗中带来了有希望的未来。在本文中，我们总结了 CHM 治疗银屑病的现有治疗机制。
