Hippius H, Matussek N
Psychopathology. 1986;19 Suppl 2:132-5. doi: 10.1159/000285144.
The therapy of depressions with amine precursors is based on the hypothesis of an amine deficiency in depression. A brief review of different trials with these substances is given. However, the therapeutic effects achieved were not satisfactory, although treatment with 5-HT or with amine precursors combined with lithium or MAO-inhibitors seemed to be more successful. Furthermore, the difficulties in interpreting these somewhat disappointing results is pointed out.
用胺前体治疗抑郁症是基于抑郁症存在胺缺乏的假说。本文对使用这些物质的不同试验进行了简要综述。然而，尽管使用5-羟色胺或胺前体联合锂盐或单胺氧化酶抑制剂进行治疗似乎更为成功，但所取得的治疗效果并不令人满意。此外，还指出了解释这些多少有些令人失望的结果所存在的困难。
