Høj Nielsen A, Knudsen F
Scand J Clin Lab Invest. 1987 Apr;47(2):175-8.
Accumulating information concerning the structure of angiotensinogen suggests a resemblance of this component of the renin-angiotensin system to the acute-phase protein alpha 1-antitrypsin. Compared to a group of age- and sex-matched controls without signs of infection, markedly elevated levels of angiotensinogen (increase in median value: 70%), alpha 1-antitrypsin (102%), caeruloplasmin (76%), haptoglobin (261%), and orosomucoid (162%) were found in plasma from 14 patients with acute inflammatory disease. This finding indicates that angiotensinogen should be included in the list of acute-phase proteins in man, and raises the question whether angiotensinogen is involved in the regulation of the renin-angiotensin system during inflammation and tissue injury.
有关血管紧张素原结构的信息不断积累，这表明肾素-血管紧张素系统的这一组成部分与急性期蛋白α1-抗胰蛋白酶存在相似之处。与一组无感染迹象、年龄和性别匹配的对照组相比，在14例急性炎症性疾病患者的血浆中发现血管紧张素原（中位数升高70%）、α1-抗胰蛋白酶（102%）、铜蓝蛋白（76%）、触珠蛋白（261%）和类黏蛋白（162%）水平显著升高。这一发现表明血管紧张素原应被列入人类急性期蛋白名单，并引发了一个问题，即血管紧张素原在炎症和组织损伤期间是否参与肾素-血管紧张素系统的调节。
