[广藿香中萜类化合物的生物合成与代谢调控：综述]

[Biosynthesis and metabolism regulation of terpenoids in Pogostemon cablin: a review].

作者信息

Yao Yin-Yi, He Meng-Ling, Li Ying-Ying, Xia Jun-Hong, Yan Han-Jing, Zhang Hong-Yi

机构信息

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University Guangzhou 510006, China.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University Guangzhou 510006, China Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials Guangzhou 510006, China Comprehensive Experimental Station of Guangzhou,Chinese Materia Medica, China Agriculture Research System Guangzhou 510006, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2021 Nov;46(21):5560-5567. doi: 10.19540/j.cnki.cjcmm.20210722.102.

DOI:10.19540/j.cnki.cjcmm.20210722.102

PMID:34951207

Abstract

The terpenoids in Pogostemon cablin have complex structures and abundant pharmacological effects. Patchouli alcohol(PA) and pogostone(PO) have a high medicinal value by virtue of anti-tumor, anti-inflammatory, antibacterial, antioxidant, and other biological activities. Due to the low content of terpenoid metabolites in P. cablin, the study of biosynthesis and metabolism regulation can provide a biosynthetic basis for obtaining high-content terpenoids. In this study, key enzyme genes in biosynthesis, transcription factors in metabolism regulation, spatio-temporal expression of terpene synthase were reviewed, aiming to provide a reference for the development, protection, and utilization of P. cablin resources.

摘要

广藿香中的萜类化合物结构复杂，药理作用丰富。广藿香醇（PA）和广藿香酮（PO）凭借抗肿瘤、抗炎、抗菌、抗氧化等生物活性具有很高的药用价值。由于广藿香中萜类代谢产物含量较低，对其生物合成和代谢调控的研究可为获得高含量萜类化合物提供生物合成依据。本研究综述了生物合成中的关键酶基因、代谢调控中的转录因子以及萜烯合酶的时空表达，旨在为广藿香资源的开发、保护和利用提供参考。