Firkin F C, Prewett E J, Nicholls K, Moran J
Am J Hematol. 1987 May;25(1):101-5. doi: 10.1002/ajh.2830250111.
Severe neutropenia due to selective loss from the bone marrow of cells of the entire neutrophil maturation sequence developed in a patient with Goodpasture's Syndrome and was associated with serious infections complicating continuous ambulatory peritoneal dialysis. Involvement of T-lymphocytes in the process affecting the neutrophil series was implicated by the relation between recovery from neutropenia and treatment with antithymocyte globulin (ATG). Azathioprine and corticosteroid administration failed to sustain recovery from neutropenia induced by ATG. It is concluded that ATG can provide a nonmyelotoxic form of therapy for pure white cell aplasia whose effectiveness is independent of responsiveness to other immunosuppressive agents.
一名患有肺出血肾炎综合征的患者出现了严重中性粒细胞减少症，这是由于骨髓中整个中性粒细胞成熟序列的细胞选择性丢失所致，并且与持续非卧床腹膜透析并发的严重感染相关。抗胸腺细胞球蛋白（ATG）治疗后中性粒细胞减少症恢复，提示T淋巴细胞参与了影响中性粒细胞系的过程。硫唑嘌呤和皮质类固醇给药未能维持ATG诱导的中性粒细胞减少症的恢复。得出的结论是，ATG可为纯白细胞再生障碍性贫血提供一种非骨髓毒性的治疗方式，其有效性独立于对其他免疫抑制剂的反应性。
