B细胞慢性淋巴细胞白血病中的骨髓再生障碍：抗胸腺细胞球蛋白治疗成功
Bone marrow aplasia in B cell chronic lymphocytic leukaemia: successful treatment with antithymocyte globulin.
作者信息
Singal R, Winfield D A, Greaves M
机构信息
Department of Haematology, Royal Hallamshire Hospital, Sheffield.
出版信息
J Clin Pathol. 1991 Nov;44(11):954-6. doi: 10.1136/jcp.44.11.954.
Pure red cell aplasia is a rare but well known association of chronic lymphocytic leukaemia (CLL). Pancytopenia due to bone marrow aplasia has not been previously described in CLL. A 42 year old man with B cell CLL became severely pancytopenic with bone marrow aplasia. Bone marrow culture resulted in a greatly reduced colony formation. High dose corticosteroids and intravenous immunoglobulin treatment were unsuccessful. Prompt and complete marrow recovery ensued after administration of antithymocyte globulin.
纯红细胞再生障碍性贫血是慢性淋巴细胞白血病（CLL）一种罕见但广为人知的关联病症。此前尚未有CLL患者因骨髓再生障碍导致全血细胞减少的相关描述。一名患有B细胞CLL的42岁男性出现严重全血细胞减少并伴有骨髓再生障碍。骨髓培养显示集落形成大幅减少。高剂量皮质类固醇和静脉注射免疫球蛋白治疗均未成功。给予抗胸腺细胞球蛋白后，骨髓迅速且完全恢复。
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