Rasmussen E K, Ullman S, Høier-Madsen M, Sørensen S F, Halberg P
Arch Dermatol. 1987 May;123(5):601-5.
Out of 97 patients with circulating ribonucleoprotein antibodies, 44 (45%) satisfied the criteria for systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyositis, or rheumatoid arthritis. Forty-two (43%) of the 97 patients whose cases did not fulfill these criteria had at least two of the following three clinical manifestations: arthritis, Raynaud's phenomenon, and swollen or sclerotic fingers. A fifth of the latter group of patients had chronic, restrictive pulmonary disease or myopathy and two thirds had hypergammaglobulinemia, IgM rheumatoid factor, and sensitized epidermal nuclei. Few patients had hypocomplementemia. One patient had nephropathy. Most patients had an unchanged, benign disease course for, on the average, nine years. It is suggested that the term mixed connective tissue disease (MCTD) be reserved for such patients, and that the acronym MCTD be changed to SRA (swollen fingers, Raynaud's phenomenon, and arthritis). Treatment with glucocorticoids is necessary for only a minority of patients.
在97例存在循环核糖核蛋白抗体的患者中，44例（45%）符合系统性硬化症、系统性红斑狼疮、多发性肌炎/皮肌炎或类风湿关节炎的标准。97例不符合这些标准的患者中，42例（43%）至少有以下三种临床表现中的两种：关节炎、雷诺现象以及手指肿胀或硬化。后一组患者中有五分之一患有慢性限制性肺病或肌病，三分之二有高球蛋白血症、IgM类风湿因子以及致敏表皮细胞核。很少有患者出现补体减少。有1例患者患有肾病。大多数患者的病情平均9年无变化，呈良性病程。建议将“混合性结缔组织病”（MCTD）这一术语保留用于此类患者，并将首字母缩写词MCTD改为SRA（手指肿胀、雷诺现象和关节炎）。仅少数患者需要使用糖皮质激素治疗。
