Behl B, Goppelt-Strübe M, Schwinzer B, Wiebe K, Resch K
Biochem Biophys Res Commun. 1987 May 14;144(3):1303-12. doi: 10.1016/0006-291x(87)91452-5.
The release of IP3 and the incorporation of arachidonic acid into phospholipids was measured in a stimulated murine alloantigen-specific, non-cytolytic T cell clone. While Concanavalin A provoked a sharp increase in IP3, Interleukin 2 had no effect on the production of IP3. An increased reacylation of phospholipids with arachidonic acid was seen within the first 4 hours after addition of Concanavalin A, while an effect upon Interleukin 2 was only observed after 8 hours of incubation with Interleukin 2. A similar retarded response to Interleukin 2 was observed in proliferation experiments. These retarded cell responses may be due to changed properties of IL 2 receptors induced by IL 2.
在一个受刺激的小鼠同种异体抗原特异性非细胞溶解性T细胞克隆中，检测了肌醇三磷酸（IP3）的释放以及花生四烯酸掺入磷脂的情况。虽然刀豆球蛋白A会引起IP3急剧增加，但白细胞介素2对IP3的产生没有影响。添加刀豆球蛋白A后的最初4小时内，可见磷脂与花生四烯酸的再酰化增加，而与白细胞介素2孵育8小时后才观察到对白细胞介素2的影响。在增殖实验中也观察到对白细胞介素2的类似延迟反应。这些延迟的细胞反应可能是由于白细胞介素2诱导的白细胞介素2受体特性改变所致。
