Fouriezos G, Walker S, Rick J, Bielajew C
Behav Brain Res. 1987 Apr;24(1):73-80. doi: 10.1016/0166-4328(87)90037-4.
The post-stimulation excitability of neurons mediating electrical self-stimulation of the anterior basal forebrain was evaluated psychophysically in the rat. Rats with electrodes in the nucleus accumbens, caudate nucleus, lateral preoptic area, diagonal band, or anterior medial forebrain bundle pressed a lever to earn 0.5-s trains of conditioning (C) and test (T) pulse pairs. The C-T interval was systematically varied and the effectiveness of the T-pulse was estimated by measuring the frequency of pulse pairs required to sustain criterion responding. All sites tested demonstrated similar recovery; T-pulse effectiveness, normalized against the effect of the C-pulse, was lowest at delays of 0.4-0.8 ms and it rose monotonically until 5 ms when it achieved an effectiveness plateau of one. Increasing the current of the T-pulse by 50 or 60% failed to hasten recovery, suggesting that the recovery profiles primarily reflect the activation of neurons very soon after emergence from absolute refractoriness. Compared to lateral hypothalamic and ventral tegmental self-stimulation, the neurons that support self-stimulation in the ventral basal forebrain recover more slowly; recovery here is only about half done by the time lateral hypothalamic placements demonstrate complete recovery.
在大鼠中，通过心理物理学方法评估了介导前基底前脑电自我刺激的神经元的刺激后兴奋性。在伏隔核、尾状核、外侧视前区、斜角带或前内侧前脑束植入电极的大鼠按压杠杆以获得0.5秒的条件（C）和测试（T）脉冲对序列。系统地改变C-T间隔，并通过测量维持标准反应所需的脉冲对频率来估计T脉冲的有效性。所有测试部位均表现出相似的恢复情况；相对于C脉冲的效果进行归一化处理后，T脉冲的有效性在延迟0.4-0.8毫秒时最低，并单调上升，直至5毫秒时达到有效性平稳期，此时有效性为1。将T脉冲电流增加50%或60%未能加速恢复，这表明恢复曲线主要反映了神经元从绝对不应期出现后很快被激活的情况。与下丘脑外侧和腹侧被盖区的自我刺激相比，支持腹侧基底前脑自我刺激的神经元恢复得更慢；当下丘脑外侧部位显示完全恢复时，此处的恢复仅完成了约一半。
