Ingram L, Mott M G, Mann J R, Raafat F, Darbyshire P J, Morris Jones P H
Br J Cancer. 1987 Apr;55(4):463-6. doi: 10.1038/bjc.1987.91.
Eight children treated between 1977 and 1983 with the UK Children's Cancer Study Group's non-Hodgkin lymphoma (NHL) and T-cell protocols have developed second malignancies within 7 years of commencing treatment. Five developed acute non-lymphoblastic leukaemia and a sixth died from infection while pancytopenic with a pre-leukaemic marrow. The other malignancies were cerebral astrocytoma and an undifferentiated low grade sarcoma. These eight children were included among 261 children studied in the first UKCCSG NHL and T-cell trials giving an actuarial incidence of 7.8% second malignancy at 7 years. Six had received adjuvant radiotherapy which may have contributed to the high incidence of second malignancy.
1977年至1983年间，按照英国儿童癌症研究组的非霍奇金淋巴瘤（NHL）和T细胞方案接受治疗的8名儿童在开始治疗后的7年内发生了第二种恶性肿瘤。5名儿童患上了急性非淋巴细胞白血病，第6名儿童在全血细胞减少且骨髓呈白血病前期时死于感染。其他恶性肿瘤为脑星形细胞瘤和未分化的低级别肉瘤。在英国儿童癌症研究组的首次NHL和T细胞试验研究的261名儿童中包括了这8名儿童，7年时第二种恶性肿瘤的精算发病率为7.8%。其中6名儿童接受了辅助放疗，这可能是导致第二种恶性肿瘤高发病率的原因。
