同时性或分期性切除结直肠癌肝转移：13 年机构随访。
Simultaneous or staged resection of synchronous colorectal cancer liver metastases: a 13-year institutional follow-up.
机构信息
Department of Surgery in Linköping, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Department of Surgery in Linköping, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
出版信息
HPB (Oxford). 2022 Jul;24(7):1091-1099. doi: 10.1016/j.hpb.2021.11.019. Epub 2021 Dec 2.
BACKGROUND
This study compared postoperative outcomes and survival rates of patients who underwent simultaneous or staged resection for synchronous colorectal cancer liver metastases.
METHODS
Between 2005 and 2018, 126 patients were registered prospectively at a university hospital in Sweden, 63 patients who underwent simultaneous resection were matched against 63 patients who underwent staged resection.
RESULTS
The length of hospital stay was shorter for the simultaneous resection group, at 11 vs 16 days, p = <0.001. Fewer patients experienced recurrence in the simultaneous resection group 39 vs 50 patients, p = 0.012. There were no significant differences in disease-free survival and overall survival between the groups. Age (hazard ratio [HR] 1.72; 95% CI 1.01-2.94; p = 0.049) and Clavien-Dindo score (HR 2.22; 95% CI 1.06-4.67; p = 0.035) had impact on survival.
CONCLUSION
Colorectal cancer with synchronous liver metastases can be resected simultaneously, and enables a shorter treatment time without jeopardizing oncological outcomes.
背景
本研究比较了同期和分期切除治疗同时性结直肠癌肝转移的术后结果和生存率。
方法
2005 年至 2018 年，瑞典一家大学医院前瞻性登记了 126 例患者，其中 63 例行同期切除术，与 63 例行分期切除术的患者相匹配。
结果
同期切除术组的住院时间更短，为 11 天 vs 16 天，p<0.001。同期切除术组复发患者较少（39 例 vs 50 例），p=0.012。两组之间无疾病无进展生存率和总生存率差异无统计学意义。年龄（风险比[HR]1.72；95%可信区间 1.01-2.94；p=0.049）和 Clavien-Dindo 评分（HR 2.22；95%可信区间 1.06-4.67；p=0.035）对生存有影响。
结论
同时性结直肠癌肝转移可以同期切除，治疗时间更短，而不会影响肿瘤学结果。
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