Department of Vascular Surgery, The Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing, China Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
Department of Vascular Surgery, The Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing, China Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
Ann Vasc Surg. 2022 Aug;84:322-326. doi: 10.1016/j.avsg.2021.12.011. Epub 2021 Dec 22.
To explore the association between SII (Systemic Immune-Inflammation Index) and PAD (peripheral arterial disease) in American adults.
Related data from NHANES (National Health and Nutrition Examination Survey) database (1999-2004) were collected and analyzed. PAD was diagnosed by ankle brachial index assessment. The association between SII and prevalent PAD was assessed using multivariable logistic regression.
A total of 6,576 eligible subjects (including 6117 subjects without PAD and 459 with PAD) were finally enrolled in the study, among which there were 3,187 females and 3,389 males with a mean SII of 585.3 ± 401.5. The age of the subjects with PAD was larger compared to those without PAD (70.2 ± 11.8 vs. 58.7 ± 12.5), and the incidence of chronic diseases, that's CAD, diabetes and hypertension, was higher in those without PAD (P < 0.001). Multivariable logistic regression indicated that a high SII level was an independent risk factor for PAD (OR = 1.51, 95% CI: 1.18- 1.93, P = 0.0012) after adjusting for body mass index, race, sex, age, diabetes mellitus (yes/no), hypertension (yes/no), and cardiovascular disease (yes/no).
It is suggested that a higher SII is associated with a higher risk of PAD.
探讨美国成年人中 SII（全身免疫炎症指数）与 PAD（外周动脉疾病）之间的关联。
收集并分析了来自 NHANES（国家健康和营养检查调查）数据库（1999-2004 年）的相关数据。通过踝臂指数评估诊断 PAD。使用多变量逻辑回归评估 SII 与 PAD 患病率之间的关系。
共有 6576 名符合条件的受试者（包括 6117 名无 PAD 受试者和 459 名 PAD 受试者）最终纳入研究，其中女性 3187 名，男性 3389 名，平均 SII 为 585.3±401.5。PAD 组的年龄大于无 PAD 组（70.2±11.8 岁 vs. 58.7±12.5 岁），无 PAD 组患有慢性疾病（即 CAD、糖尿病和高血压）的比例更高（P<0.001）。多变量逻辑回归表明，在校正体重指数、种族、性别、年龄、糖尿病（是/否）、高血压（是/否）和心血管疾病（是/否）后，高 SII 水平是 PAD 的独立危险因素（OR=1.51，95%CI：1.18-1.93，P=0.0012）。
提示较高的 SII 与 PAD 风险增加相关。
