Liu Qiang, Wu Xing, Wang Yun, Wang Xiang, Zhao Fei, Shi Jianjun
Department of Cardiovascular Surgery, Taiyuan Central Hospital, Taiyuan, Shanxi, China.
Department of Cardiovascular Surgery, The Ninth Clinical College Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
PLoS One. 2025 Mar 24;20(3):e0320356. doi: 10.1371/journal.pone.0320356. eCollection 2025.
The relationship between the amount of dietary vitamin E consumed and the development of peripheral arterial disease (PAD) remains a topic of debate. This relationship is of the utmost importance in the realms of healthcare and public health and is currently a highly researched and prominent topic. This study aimed to present the relationship between dietary vitamin E intake and PAD.
In a retrospective cross-sectional analysis, data from 6,588 participants in the National Health and Nutrition Examination Survey of the United States were examined during the period 1999-2004. We collected data on age, sex, race, marital status, education, physical activity, income, smoking, hypertension, diabetes, cardiovascular disease, body mass index, total cholesterol and HbA1c. Logistic regression and smooth curve fitting were used to support the research objectives.
After accounting for all relevant factors, a negative correlation between dietary vitamin E intake and the likelihood of PAD was observed (OR: 0.981, 95% CI: 0.957-1.004). The overall prevalence of PAD was 5.9%, with 49.6% in males and 50.4% in females. Individuals in the third quartile of dietary vitamin E intake had a lower occurrence rate of peripheral artery disease than those in the first quartile (OR: 0.68, 95% CI: 0.51, 0.91). Similar patterns of association were observed in the subgroup analysis (all P values for interaction were > 0.05).
Our study suggests a negative association between dietary vitamin E intake and incidence of PAD. Therefore individuals with insufficient dietary vitamin E intake, especially those with a very low intake, should consider increasing their vitamin E intake to lower the risk of developing PAD. These findings should be considered when offering dietary guidance and nutrition education to prevent PAD.
膳食中维生素E的摄入量与外周动脉疾病（PAD）的发生之间的关系仍是一个有争议的话题。这种关系在医疗保健和公共卫生领域至关重要，目前是一个研究深入且备受关注的话题。本研究旨在阐述膳食维生素E摄入量与PAD之间的关系。
在一项回顾性横断面分析中，对1999 - 2004年期间美国国家健康与营养检查调查中6588名参与者的数据进行了检查。我们收集了年龄、性别、种族、婚姻状况、教育程度、身体活动、收入、吸烟、高血压、糖尿病、心血管疾病、体重指数、总胆固醇和糖化血红蛋白的数据。采用逻辑回归和平滑曲线拟合来支持研究目标。
在考虑所有相关因素后，观察到膳食维生素E摄入量与PAD发生可能性之间呈负相关（比值比：0.981，95%置信区间：0.957 - 1.004）。PAD的总体患病率为5.9%，男性为49.6%，女性为50.4%。膳食维生素E摄入量处于第三个四分位数的个体外周动脉疾病发生率低于第一个四分位数的个体（比值比：0.68，95%置信区间：0.51，0.91）。在亚组分析中观察到类似的关联模式（所有交互作用的P值均>0.05）。
我们的研究表明膳食维生素E摄入量与PAD发病率之间存在负相关。因此，膳食维生素E摄入量不足的个体，尤其是摄入量极低的个体，应考虑增加维生素E摄入量以降低发生PAD的风险。在提供预防PAD的饮食指导和营养教育时应考虑这些发现。
