Hoey Richard, Sharpe Eva, Kukula Angela, Workman Paul
The Institute of Cancer Research, London, UK.
The Institute of Cancer Research, London, UK; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
Drug Discov Today. 2022 Apr;27(4):946-950. doi: 10.1016/j.drudis.2021.12.015. Epub 2021 Dec 22.
New discoveries and technologies are driving major advances in our understanding of cancer and underpinning a new era of precision medicine and immunotherapy. However, advances in treatment have been uneven: whereas survival rates for some common cancers are improving rapidly, for others there has been much less progress. In addition, healthcare systems are finding it difficult to provide access to expensive new treatments. There is an urgent need for imaginative policy solutions to incentivise the creation of novel therapies that address the full range of cancer-causing mechanisms. We have worked with organisations across the medical research community to develop consensus statements on how to enhance access to innovative cancer drugs. Here, we present our reflections on these statements.
新发现和新技术正在推动我们对癌症的理解取得重大进展,并为精准医学和免疫疗法的新时代奠定基础。然而,治疗方面的进展并不均衡:一些常见癌症的生存率正在迅速提高,而其他癌症的进展则要小得多。此外,医疗保健系统发现难以提供昂贵的新疗法。迫切需要富有想象力的政策解决方案,以激励开发针对各种致癌机制的新型疗法。我们与医学研究界的各个组织合作,就如何增加创新癌症药物的可及性制定了共识声明。在此,我们阐述对这些声明的思考。