[Different levels of differentiation of blood leukemia cells in patients with chronic lymphoid leukemia].

The immunological phenotype of blood leukemic cell samples derived from 52 patients with B-cellular chronic lympholeukemia (B-CLL) was defined with the use of monoclonal antibodies and antisera to differentiation antigens and immunoglobulins. Leukemic cells were divided into 6 groups according to the stages of B-cell lineage differentiation: pre-B-cells, early and late antigen-independent stages and three consecutive antigen-dependent stages of differentiation. It was established that in case of B-CLL phenotypic characteristics of later stages of B-lymphocyte differentiation dominated.