Seligmann M, Vogler L B, Preud'Homme J L, Guglielmi P, Brouet J C
Blood Cells. 1981;7(2):237-46.
The recent results are summarized of some immunological studies of various human leukemias of the B-cell lineage. The study of pre-B leukemias has outlined the diversity of immunoglobulin expression in leukemic cells resembling B-lymphocyte precursors and has provided insights into the biology of the progenitors of hematopoietic cells. Acute leukemia with Burkitt cells represents a very homogeneous group close to classical Burkitt's lymphoma. Mitogens are able to induce in vitro differentiation of leukemic cells from chronic lymphocytic-B leukemia and from hairy cell leukemia. Hairy cells become able to express new phenotypic characteristics after stimulation by phytohemagglutinin.
总结了近期对各种B细胞系人类白血病的一些免疫学研究结果。前B白血病的研究勾勒出了白血病细胞中免疫球蛋白表达的多样性，这些白血病细胞类似于B淋巴细胞前体，并为造血细胞祖细胞的生物学特性提供了见解。伴有伯基特细胞的急性白血病是一个非常同质的群体，与经典的伯基特淋巴瘤相近。丝裂原能够在体外诱导慢性B淋巴细胞白血病和毛细胞白血病的白血病细胞分化。毛细胞在受到植物血凝素刺激后能够表达新的表型特征。
