澳大利亚社区用于治疗儿童癫痫的手工大麻产品中污染物的测定：“PELICAN”研究的子分析。
Determination of contaminants in artisanal cannabis products used for childhood epilepsy in the Australian community: A sub-analysis of the 'PELICAN' study.
机构信息
The University of Sydney, Lambert Initiative for Cannabinoid Therapeutics, Sydney, Australia; The University of Sydney, Brain and Mind Centre, Sydney, Australia; The University of Sydney, Faculty of Science, School of Psychology, Sydney, Australia.
Drug and Alcohol Services, South East Sydney Local Health District, Sydney, Australia; Division Addiction Medicine, Faculty Medicine and Health, Sydney, Australia; NSW DACRIN (Drug and Alcohol Clinical Research and Improvement Network), Sydney, Australia.
出版信息
Epilepsy Behav. 2022 Feb;127:108496. doi: 10.1016/j.yebeh.2021.108496. Epub 2021 Dec 23.
Despite recent approval of pharmaceutical-grade cannabis products for the treatment of childhood epilepsy, some families continue to use artisanal cannabis products as a way to manage seizures in their children. However, such products are typically of unknown composition and quality, and may therefore pose an unpredictable health risk to the child. In the present analysis, 78 samples of cannabis products collected (as part of a previous study) from families of children with epilepsy (average age 8.8 ± 4.6 years) were analyzed for heavy metals (arsenic, cadmium, lead, and mercury), residual solvents (panel of 19 solvents) and pesticides (panel of 57 pesticides). Due to small sample volumes obtained, only a subset of samples was used in each analysis. Results showed that no cannabis sample exceeded the toxicity limits for heavy metals (n = 51 samples tested). Of the 58 cannabis samples tested for residual solvents, 17 (29%) contained concentrations of ethanol or isopropanol above the generally accepted limit of 5000 parts per million. With the volumes consumed, it was thought unlikely that children were consuming hazardous amounts of residual solvents, although this could not be ruled out in every case. Most samples (n = 31 samples tested) yielded inconclusive results for the pesticides, although one sample contained concentrations of bifenthrin that were 4.9 times higher than the acceptable limit. Overall, these results highlight the need for improved access to quality-assured cannabis products and the education of doctors, patients, and artisanal manufacturers around the contaminant exposure risk in unregulated cannabis products.
尽管最近已经批准了药用级大麻产品用于治疗儿童癫痫，但仍有一些家庭继续使用手工制作的大麻产品来控制其孩子的癫痫发作。然而，这些产品的成分和质量通常是未知的，因此可能对儿童健康构成不可预测的风险。在本分析中，分析了从癫痫儿童家庭（平均年龄 8.8±4.6 岁）收集的 78 个大麻产品样本（作为先前研究的一部分），以检测重金属（砷、镉、铅和汞）、残留溶剂（19 种溶剂的组合）和农药（57 种农药的组合）。由于获得的样本量较小，仅使用了每个分析的一部分样本。结果表明，没有一个大麻样本超过重金属毒性限量（51 个测试样本）。在 58 个测试残留溶剂的大麻样本中，17 个（29%）样本的乙醇或异丙醇浓度超过普遍接受的 5000 百万分之限。考虑到消耗的体积，儿童不太可能摄入危险量的残留溶剂，但在每种情况下都不能排除这种可能性。大多数样本（31 个测试样本）对农药的检测结果不确定，尽管有一个样本的联苯菊酯浓度比可接受限值高 4.9 倍。总的来说，这些结果强调了需要更好地获得质量保证的大麻产品，并教育医生、患者和手工制造商了解不受监管的大麻产品中的污染物暴露风险。
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