Haftek M, Jabłońska S, Szymańczyk J, Jarzabek-Chorzelska M
Dermatologica. 1987;174(4):173-9. doi: 10.1159/000249168.
T cell defect and energy to contact sensitizers are characteristic of the depressed cell-mediated immunity in epidermodysplasia verruciformis (EV). In this disease the generalized infection with human papilloma viruses is associated with a high risk of skin cancers. Langerhans cell density was studied quantitatively in lesions and noninvolved epidermis of EV using OKT6 and anti-HLA-DR monoclonal antibodies with indirect immunofluorescence technique. No significant changes were found in apparently normal skin suggesting no primary defect of Langerhans cells in EV. A marked decrease in Langerhans cell number per unit of epidermal volume could be observed in EV lesions. This additional reduction of immunological surveillance at sites of potentially oncogenic human papilloma virus infection may contribute to the increased risk of malignant transformation in EV lesions.
T细胞缺陷以及对接触性致敏原的反应能力是疣状表皮发育不良（EV）中细胞介导免疫功能低下的特征。在这种疾病中，人乳头瘤病毒的全身性感染与皮肤癌的高风险相关。使用OKT6和抗HLA - DR单克隆抗体，采用间接免疫荧光技术对EV患者的皮损及未受累表皮中的朗格汉斯细胞密度进行了定量研究。在外观正常的皮肤中未发现明显变化，提示EV患者的朗格汉斯细胞无原发性缺陷。在EV皮损中可观察到每单位表皮体积内朗格汉斯细胞数量显著减少。在潜在致癌性人乳头瘤病毒感染部位免疫监视功能的这种额外降低，可能导致EV皮损发生恶性转化的风险增加。
