Aoyama H, Seki S, Abo T, Usuba Y, Tomita Y, Tagami H
Department of Dermatology, School of Medicine, Tohoku University, Sendai, Japan.
Acta Derm Venereol. 1993 Feb;73(1):52-4. doi: 10.2340/00015555735254.
A 40-year-old man with epidermodysplasia verruciformis showed a decrease in peripheral blood T cells and abnormal expansion of large granular lymphocytes, accompanied by increased natural killer cell activity. Surface marker analysis of his large granular lymphocytes demonstrated that the subset, CD 57+ and CD 16+, had increased. His father, who had no skin lesions of epidermodysplasia verruciformis, displayed similar blood changes and his brother showed a decrease in T cells and a slight increase in CD 16+ natural killer cells, whereas his mother revealed only a slight decrease in T cells. Our present study indicates that epidermodysplasia verruciformis might be associated with hereditary abnormal expansion of large granular lymphocytes and a decrease in T cells.
一名患有疣状表皮发育不良的40岁男性表现为外周血T细胞减少和大颗粒淋巴细胞异常扩增，同时自然杀伤细胞活性增加。对其大颗粒淋巴细胞的表面标志物分析显示，CD 57+和CD 16+亚群有所增加。他的父亲没有疣状表皮发育不良的皮肤病变，但表现出类似的血液变化，他的哥哥T细胞减少，CD 16+自然杀伤细胞略有增加，而他的母亲仅表现出轻微的T细胞减少。我们目前的研究表明，疣状表皮发育不良可能与大颗粒淋巴细胞的遗传性异常扩增和T细胞减少有关。
