一种对人甲状腺细胞具有特异性细胞毒性的甲状腺内T细胞克隆。
An intrathyroidal T-cell clone specifically cytotoxic for human thyroid cells.
作者信息
Mackenzie W A, Davies T F
出版信息
Immunology. 1987 May;61(1):101-3.
Abstract
We have isolated the first human T-cell clone (IM8) that is specifically cytotoxic to autologous human thyroid cells. In order to obtain primary immunologically reactive cells in patients with autoimmune thyroiditis, we cloned, by limiting dilution, in vivo activated intrathyroidal T lymphocytes against thyroid antigens. Clone IM8 expresses CD8 surface antigen, has no activity against autologous or allogeneic mitogen-stimulated lymphoblast cells or allogeneic thyroid cells, and does not lyse K562 cells, implying a lack of natural killer (NK) activity. This observation suggests a role for IM8-like clones in the immunopathology of human autoimmune thyroid disease.
摘要
我们分离出了首个对自体人甲状腺细胞具有特异性细胞毒性的人T细胞克隆（IM8）。为了在自身免疫性甲状腺炎患者中获得具有初级免疫反应性的细胞，我们通过有限稀释法克隆了体内针对甲状腺抗原而被激活的甲状腺内T淋巴细胞。克隆IM8表达CD8表面抗原，对自体或同种异体丝裂原刺激的淋巴母细胞或同种异体甲状腺细胞无活性，并且不裂解K562细胞，这意味着缺乏自然杀伤（NK）活性。这一观察结果提示了IM8样克隆在人类自身免疫性甲状腺疾病免疫病理学中的作用。
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