Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, Ospedale Civile Sant'Agostino-Estense, University of Modena and Reggio Emilia, Modena, Italy.
International PhD School in Clinical and Experimental Medicine (CEM), University of Modena and Reggio Emilia, Modena, Italy.
Front Endocrinol (Lausanne). 2021 Dec 8;12:791763. doi: 10.3389/fendo.2021.791763. eCollection 2021.
An increasing number of pollutants with endocrine disrupting potential are accumulating in the environment, increasing the exposure risk for humans. Several of them are known or suspected to interfere with endocrine signals, impairing reproductive functions. Follicle-stimulating hormone (FSH) is a glycoprotein playing an essential role in supporting antral follicle maturation and may be a target of disrupting chemicals (EDs) likely impacting female fertility. EDs may interfere with FSH-mediated signals at different levels, since they may modulate the mRNA or protein levels of both the hormone and its receptor (FSHR), perturb the functioning of partner membrane molecules, modify intracellular signal transduction pathways and gene expression. studies and animal models provided results helpful to understand ED modes of action and suggest that they could effectively play a role as molecules interfering with the female reproductive system. However, most of these data are potentially subjected to experimental limitations and need to be confirmed by long-term observations in human.
越来越多具有内分泌干扰潜力的污染物在环境中积累，增加了人类的暴露风险。其中一些已知或疑似干扰内分泌信号，损害生殖功能。卵泡刺激素 (FSH) 是一种糖蛋白，在支持窦卵泡成熟方面发挥着重要作用，可能是破坏化学物质 (EDs) 的靶点，这些化学物质可能会影响女性的生育能力。EDs 可能会在不同水平上干扰 FSH 介导的信号，因为它们可能调节激素及其受体 (FSHR) 的 mRNA 或蛋白水平，扰乱伴侣膜分子的功能，改变细胞内信号转导途径和基因表达。研究和动物模型提供了有助于了解 ED 作用模式的结果，并表明它们可能作为干扰女性生殖系统的分子有效发挥作用。然而，这些数据大多可能存在实验局限性，需要在人类中进行长期观察来证实。
