肯尼亚女性月经过多相关的甲状腺及生殖激素因素
Thyroid and reproductive hormonal factors associated with menorrhagia among women in Kenya.
作者信息
Marabi Phidelis M, Kosiyo Paul M, Musyoki Stanslaus K, Ouma Collins
机构信息
Department of Medical Laboratory Sciences, School of Health Sciences, Kisii University, Kisii, Kenya.
Department of Biomedical Sciences, Faculty of Public Health and Community Development, Maseno University, Maseno, Kenya.
出版信息
Afr J Lab Med. 2025 Apr 10;14(1):2653. doi: 10.4102/ajlm.v14i1.2653. eCollection 2025.
BACKGROUND
Menorrhagia, characterised by menstrual blood loss exceeding 80 mL per cycle, is a common issue in Western Kenya. However, there are insufficient data on how hormonal disorders contribute to its occurrence.
OBJECTIVE
This study aimed to examine the differences and associations between thyroid and reproductive hormone levels in women with menorrhagia versus those without, in Bungoma County, Kenya.
METHODS
A comparative cross-sectional study was conducted among 428 women (214 with menorrhagia and 214 controls) aged 18-45 years, between 01 December 2022 and 31 September 2023 at Bungoma County Referral Hospital. The analysis included thyroid stimulating hormone, total and free triiodothyronine, thyroxine, follicle stimulating hormone (FSH), luteinising hormone, prolactin, oestrogen, progesterone, and testosterone.
RESULTS
Women experiencing menorrhagia had statistically significant increases in levels of FSH ( < 0.0001), oestrogen ( < 0.001), and total testosterone ( < 0.001), while prolactin levels had a statistically significant decrease ( < 0.001) compared to those without menorrhagia. There were no statistically significant differences in total triiodothyronine ( = 0.384), free triiodothyronine ( = 0.610), total thyroxine ( = 0.127), free thyroxine ( = 0.360), or thyroid stimulating ( = 0.118). No associations were found between menorrhagia and either thyroid or reproductive hormones.
CONCLUSION
Elevated levels of FSH, oestrogen, and testosterone, along with reduced prolactin, may serve as potential biomarkers for diagnosing menorrhagia in premenopausal or reproductively aged women. A screening tool that integrates these hormonal markers could improve the accuracy of diagnosis and optimise treatment strategies in primary healthcare settings.
WHAT THIS STUDY ADDS
The study suggests that levels of FSH, oestrogen, total testosterone, and prolactin differ significantly between women with and without menorrhagia, indicating their potential use in predicting the condition.
背景
月经过多表现为每个月经周期失血超过80毫升，是肯尼亚西部的一个常见问题。然而，关于激素紊乱如何导致其发生的数据不足。
目的
本研究旨在调查肯尼亚邦戈马县月经过多女性与无月经过多女性甲状腺激素和生殖激素水平的差异及关联。
方法
2022年12月1日至2023年9月31日期间，在邦戈马县转诊医院对428名年龄在18至45岁的女性（214名月经过多患者和214名对照者）进行了一项比较横断面研究。分析包括促甲状腺激素、总三碘甲状腺原氨酸和游离三碘甲状腺原氨酸、甲状腺素、促卵泡激素（FSH）、促黄体生成素、催乳素、雌激素、孕酮和睾酮。
结果
与无月经过多的女性相比，月经过多的女性FSH水平（<0.0001）、雌激素水平（<0.001）和总睾酮水平（<0.001）有统计学显著升高，而催乳素水平有统计学显著降低（<0.001）。总三碘甲状腺原氨酸（=0.384）、游离三碘甲状腺原氨酸（=0.610）、总甲状腺素（=0.127）、游离甲状腺素（=0.360）或促甲状腺激素（=0.118）无统计学显著差异。未发现月经过多与甲状腺激素或生殖激素之间存在关联。
结论
FSH、雌激素和睾酮水平升高以及催乳素降低可能是绝经前或育龄期女性月经过多诊断的潜在生物标志物。整合这些激素标志物的筛查工具可提高基层医疗环境中诊断的准确性并优化治疗策略。
本研究的新增内容
该研究表明，月经过多女性与无月经过多女性的FSH、雌激素、总睾酮和催乳素水平存在显著差异，表明它们在预测该病症方面具有潜在用途。
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