Lv Quanzhen, Yan Lan, Jiang Yuanying
School of Pharmacy, Naval Medical University, Shanghai, China.
Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Front Microbiol. 2021 Dec 9;12:779176. doi: 10.3389/fmicb.2021.779176. eCollection 2021.
The vacuole of plays a significant role in many processes including homeostasis control, cellular trafficking, dimorphic switching, and stress tolerance. Thus, understanding the factors affecting vacuole function is important for the identification of new drug targets needed in response to the world's increasing levels of invasive infections and the growing issue of fungal drug resistance. Past studies have shown that vacuolar proton-translocating ATPases (V-ATPases) play a central role in pH homeostasis and filamentation. Vacuolar protein sorting components (VPS) regulate V-ATPases assembly and at the same time affect hyphal development. As well, vacuolar calcium exchange systems like Yvc1 and Pmc1 maintain cytosolic calcium levels while being affected by V-ATPases function. All these proteins play a role in the virulence and pathogenesis of . This review highlights the relationships among V-ATPases, VPS, and vacuolar calcium exchange proteins while summarizing their importance in infections.
液泡在许多过程中发挥着重要作用，包括稳态控制、细胞运输、二态转换和应激耐受性。因此，了解影响液泡功能的因素对于确定应对全球侵袭性感染水平上升和真菌耐药性日益严重问题所需的新药物靶点非常重要。过去的研究表明，液泡质子转运ATP酶（V-ATP酶）在pH稳态和丝状化中起核心作用。液泡蛋白分选组件（VPS）调节V-ATP酶的组装，同时影响菌丝发育。此外，像Yvc1和Pmc1这样的液泡钙交换系统在维持胞质钙水平的同时，也受到V-ATP酶功能的影响。所有这些蛋白质都在（此处原文缺失具体对象）的毒力和发病机制中发挥作用。本综述强调了V-ATP酶、VPS和液泡钙交换蛋白之间的关系，同时总结了它们在（此处原文缺失具体对象）感染中的重要性。
