Gong Xueqi, Li Hemei, Zhao Yiqing
Reproductive Medicine Center, Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Avenue, Wuhan 430030, China.
Reproductive Medicine Center, Department of Gynecology and Obstetrics, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology 26 Shengli Avenue, Wuhan 430014, China.
Am J Transl Res. 2021 Nov 15;13(11):13167-13172. eCollection 2021.
To report a case of successful ovarian stimulation and pregnancy in an infertile woman with Rathke's cleft cyst (RCC).
This is a case report of a 32-year-old infertile woman with RCC presenting with secondary amenorrhea and hypogonadotropic hypogonadism (HH). Three rounds of ovarian stimulation and ovulation induction by means of HMG and HCG were performed (two before HSG and one after HSG). HSG was performed after two rounds of ovulation induction without pregnancy to assess the fallopian tubes and uterine cavity of the patient. Serum beta-human chorionic gonadotropin (β-HCG) and ultrasound examination were performed after the third round of ovulation induction to confirm successful pregnancy.
HSG revealed that the uterine cavity was normal and that the bilateral fallopian tubes were unobstructed. Four weeks after the third round of ovulation induction, the β-HCG test was positive (10261 μg/L), and ultrasound examination showed an intrauterine early gestational sac with an embryo (10*7 mm) and a primitive heart tube pulse.
Infertility accompanied by RCC is rare in the clinic. Clarifying the cause of infertility and secondary amenorrhea is very important for achieving a successful pregnancy. This case demonstrates that such infertility can be treated effectively with ovarian stimulation and ovulation induction using HMG and HCG. To the best of our knowledge, this is the first case report of infertility accompanied by RCC.
报告一例患有拉克氏裂囊肿（RCC）的不孕女性成功进行卵巢刺激并怀孕的病例。
这是一例32岁患有RCC的不孕女性病例报告，该患者表现为继发性闭经和低促性腺激素性性腺功能减退（HH）。通过人绝经期促性腺激素（HMG）和人绒毛膜促性腺激素（HCG）进行了三轮卵巢刺激和排卵诱导（两轮在子宫输卵管造影术（HSG）之前，一轮在HSG之后）。在两轮排卵诱导未怀孕后进行HSG，以评估患者的输卵管和子宫腔。在第三轮排卵诱导后进行血清β-人绒毛膜促性腺激素（β-HCG）检测和超声检查，以确认成功怀孕。
HSG显示子宫腔正常，双侧输卵管通畅。在第三轮排卵诱导四周后，β-HCG检测呈阳性（10261μg/L），超声检查显示宫内早孕囊，有一个胚胎（10*7mm）和原始心管搏动。
临床上伴有RCC的不孕症很少见。明确不孕和继发性闭经的原因对于成功怀孕非常重要。该病例表明，使用HMG和HCG进行卵巢刺激和排卵诱导可以有效治疗此类不孕症。据我们所知，这是首例伴有RCC的不孕症病例报告。
