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病例报告：小儿恶性萎缩性丘疹病伴小肠穿孔及抗心磷脂抗体阳性

Case Report: Pediatric Malignant Atrophic Papulosis With Small Bowel Perforation and Positivity of Anticardiolipin Antibody.

作者信息

Wang Hai-Qing, Guan Yu, Gong Xiao-Pan, Chen You-Tao, Ji Chao

机构信息

Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Department of Dermatology, Fujian Children's Hospital, Fuzhou, China.

出版信息

Front Pediatr. 2021 Dec 10;9:764797. doi: 10.3389/fped.2021.764797. eCollection 2021.

DOI:10.3389/fped.2021.764797
PMID:34956979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8703221/
Abstract

Malignant atrophic papulosis (MAP) is a life-threatening vasculopathy affecting the skin, gastrointestinal tract, central nervous system, pleural membrane, and pericardium. MAP carries a poor prognosis primarily because of its systemic involvement. It is extremely rare in children. Herein, we report a pediatric case of MAP with small bowel perforation and anticardiolipin antibody positivity.

摘要

恶性萎缩性丘疹病（MAP）是一种危及生命的血管病，可累及皮肤、胃肠道、中枢神经系统、胸膜和心包。MAP预后较差，主要是因为其累及全身。该病在儿童中极为罕见。在此，我们报告一例患有小肠穿孔且抗心磷脂抗体阳性的儿童MAP病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/830d201e48e9/fped-09-764797-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/0a591523b733/fped-09-764797-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/5ae76c9c0792/fped-09-764797-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/18b897177a66/fped-09-764797-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/830d201e48e9/fped-09-764797-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/0a591523b733/fped-09-764797-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/5ae76c9c0792/fped-09-764797-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/18b897177a66/fped-09-764797-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d93/8703221/830d201e48e9/fped-09-764797-g0004.jpg

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Malignant Atrophic Papulosis.恶性萎缩性丘疹病
JAMA Dermatol. 2020 Feb 1;156(2):204. doi: 10.1001/jamadermatol.2019.3726.
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Degos disease, not just a scar: lethal outcome in spite of immunomodulatory therapy.迪戈斯病，不仅仅是一道疤痕：尽管进行了免疫调节治疗仍有致命后果。
J Eur Acad Dermatol Venereol. 2017 Oct;31(10):e435-e438. doi: 10.1111/jdv.14245. Epub 2017 May 4.
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Congenital Degos Disease: Case Report and Dermoscopic Findings.先天性德戈斯病：病例报告及皮肤镜检查结果
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The dermoscopic variability of Degos disease at different stages of progression.迪戈斯病在不同进展阶段的皮肤镜表现差异
Dermatol Pract Concept. 2014 Jul 31;4(3):59-61. doi: 10.5826/dpc.0403a11. eCollection 2014 Jul.
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Degos disease with an intestinal perforation: a case report.
Int J Dermatol. 2014 May;53(5):631-4. doi: 10.1111/j.1365-4632.2012.05602.x. Epub 2014 Feb 14.
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The effects of Eculizumab on the pathology of malignant atrophic papulosis.依库珠单抗对恶性萎缩性丘疹病病理的影响。
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