Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Inserm, French National Research Institute for Sustainable Development (IRD), Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Matern Child Nutr. 2022 Apr;18(2):e13291. doi: 10.1111/mcn.13291. Epub 2021 Dec 26.
Access to treatment for acute malnutrition remains a challenge, in part due to the fragmentation of treatment programmes based on case severity. This paper evaluates utilization patterns, outcomes and associated costs for treating acute malnutrition cases among a cohort of children in Burkina Faso. This study is a secondary analysis of a proof-of-concept trial, called Optimizing treatment for acute Malnutrition (OptiMA), conducted in Burkina Faso in 2016. A total of 4958 eligible children whose mid-upper arm circumference (MUAC) was less than 125 mm or with oedema were followed weekly and given ready-to-use therapeutic foods (RUTF). We evaluated the service utilization and outcomes among patients and estimated resource use and variable cost per patient, and examined factors driving variation in resource use. Children with lower initial MUAC level grew faster but required more time to recover than those with higher initial MUAC level. They also had higher rates of death, default and nonresponse. The simplified OptiMA approach for treating acute malnutrition achieved high rates of recovery overall (84%), especially among less severe cases, with modest quantities of RUTF. The average overall variable cost per child admitted was US$38.0 (SD: 20.5) half of which was accounted for by the cost of RUTF. Cost per recovered case was correlated with case severity, ranging from US$35.1 to US$132.8. If simplified integrated programmes using severity-based RUTF dosing can increase access to treatment at earlier, less severe stages of acute malnutrition, they can help avoid more serious and costlier cases.
获得急性营养不良治疗仍然是一个挑战,部分原因是基于病情严重程度的治疗方案碎片化。本文评估了布基纳法索一个队列中急性营养不良病例的治疗利用模式、结果和相关成本。本研究是一项名为优化急性营养不良治疗(OptiMA)的概念验证试验的二次分析,该试验于 2016 年在布基纳法索进行。共有 4958 名符合条件的儿童入选,其上臂中部周长(MUAC)小于 125mm 或有水肿,每周随访一次,并给予即食治疗食品(RUTF)。我们评估了患者的服务利用情况和结局,并估计了每个患者的资源使用和可变成本,同时检查了资源使用变化的驱动因素。初始 MUAC 水平较低的儿童生长较快,但恢复时间比初始 MUAC 水平较高的儿童长。他们的死亡率、失访率和无应答率也较高。简化的 OptiMA 治疗急性营养不良的方法总体上实现了较高的恢复率(84%),尤其是在病情较轻的病例中,仅使用了少量的 RUTF。每个入院儿童的总可变平均成本为 38.0 美元(SD:20.5),其中一半由 RUTF 的成本构成。每例康复病例的成本与病情严重程度相关,范围为 35.1 美元至 132.8 美元。如果使用基于严重程度的 RUTF 剂量的简化综合方案能够在急性营养不良的早期、较轻阶段增加治疗机会,那么它们可以帮助避免更严重和更昂贵的病例。