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半胱氨酸蛋白酶抑制剂 C 和半胱氨酸蛋白酶抑制剂 SN 作为恶性葡萄膜黑色素瘤中可能的可溶性肿瘤标志物。

Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma.

机构信息

Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.

The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk Branch. Novosibirsk, Russia.

出版信息

Radiol Oncol. 2021 Dec 22;56(1):83-91. doi: 10.2478/raon-2021-0049.

DOI:10.2478/raon-2021-0049
PMID:34957724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8884861/
Abstract

BACKGROUND

The aim of the study was to determine the concentration of endogenous cystatin C and cystatin SN, as potential tumor biomarkers, in the serum and biological fluids of the eye in both healthy controls and patients with uveal melanoma.

PATIENTS AND METHODS

The concentration of both cystatins was determined in the intraocular fluid (IOF), tear fluid, and serum of patients with uveal melanoma and compared to baseline measurements in IOF, tears, serum, cerebral spinal fluid, saliva and urine of healthy controls.

RESULTS

The concentration of cystatin C in all the biological matrices obtained from healthy controls significantly exceeded the concentration of cystatin SN and was independent of gender. Cystatin C concentrations in the tear fluid of patients with uveal melanoma (both the eye with the malignancy, as well as the contralateral, non-affected eye), were significantly greater than cystatin C concentrations in the tear fluid of healthy controls and was independent of tumor size. The concentration of cystatin SN in IOF of patients with uveal melanoma was significantly less than the corresponding concentration of cystatin SN in healthy controls.

CONCLUSIONS

The ratio of cystatins (CysC:CysSN) in both the serum and tear fluid, as well as the concentration of cystatin SN in IOF, would appear to strongly suggest the presence of uveal melanoma. It is further suggested that multiple diagnostic criteria be utilized if a patient is suspected of having uveal melanoma, such as determination of the cystatin C and cystatin SN concentrations in serum, tears, and IOF, ocular fundus and ultrasound imaging, and biopsy with histopathological evaluation.

摘要

背景

本研究旨在确定内源性胱抑素 C 和胱抑素 SN 的浓度，作为潜在的肿瘤生物标志物，在健康对照者和葡萄膜黑色素瘤患者的血清和眼内生物液中。

患者和方法

在葡萄膜黑色素瘤患者的眼内液（IOF）、泪液和血清中测定了这两种胱抑素的浓度，并与健康对照者的 IOF、泪液、血清、脑脊液、唾液和尿液中的基线测量值进行了比较。

结果

健康对照者所有生物基质中胱抑素 C 的浓度均明显高于胱抑素 SN 的浓度，且与性别无关。葡萄膜黑色素瘤患者（包括恶性肿瘤眼和对侧未受影响的眼）的泪液中胱抑素 C 的浓度明显高于健康对照者的泪液中胱抑素 C 的浓度，且与肿瘤大小无关。葡萄膜黑色素瘤患者的 IOF 中胱抑素 SN 的浓度明显低于健康对照者的相应浓度。

结论

血清和泪液中胱抑素的比值（CysC：CysSN）以及 IOF 中胱抑素 SN 的浓度似乎强烈提示存在葡萄膜黑色素瘤。进一步建议，如果怀疑患者患有葡萄膜黑色素瘤，则应利用多种诊断标准，如确定血清、泪液和 IOF 中胱抑素 C 和胱抑素 SN 的浓度、眼部眼底和超声成像以及组织病理学评估的活检。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/7ecd38b6f607/raon-56-083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/bd01d9d8f7fc/raon-56-083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/2c39daf89e79/raon-56-083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/bbec38c79ea6/raon-56-083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/eab146ae557a/raon-56-083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/7ecd38b6f607/raon-56-083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/bd01d9d8f7fc/raon-56-083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/2c39daf89e79/raon-56-083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/bbec38c79ea6/raon-56-083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/eab146ae557a/raon-56-083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7398/8884861/7ecd38b6f607/raon-56-083-g005.jpg

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