Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil.
Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil.
Braz J Infect Dis. 2022 Jan-Feb;26(1):101667. doi: 10.1016/j.bjid.2021.101667. Epub 2021 Dec 24.
Thirteen Haemophylus influenzae invasive strains isolated from patients at Clinical Hospital of State University of Campinas, from May 2013 through August 2019, was submitted to Illumina genome sequencing HiSeq platform. Further in silico analysis of serogroup and Multi Locus Sequence Typing (MLST) from whole DNA sequencing had demonstrated the actual clonal distribution in the Campinas Metropolitan region. Thus, results showed the existence of a new ST Haemophilus influenzae found in the Brazilian territory and an increase of strains belonging to serogroup a (three strains also belonging to ST23). In conclusion, we observed an increase of non-typable H. influenzae (NTHi) and a strain involved in invasive diseases in the Campinas - São Paulo region after frequent detection of those serotypes and genotypes in other Brazilian regions.
2013 年 5 月至 2019 年 8 月，从坎皮纳斯州立大学临床医院的患者中分离出的 13 株流感嗜血杆菌侵袭株，被提交到 Illumina 基因组测序 HiSeq 平台。进一步对全 DNA 测序的血清群和多位点序列分型 (MLST) 进行的计算机分析表明，在坎皮纳斯大都市区存在实际的克隆分布。因此，结果表明在巴西领土上发现了一种新的流感嗜血杆菌 ST，并且属于血清组 a 的菌株增加（三个菌株也属于 ST23）。总之，我们观察到在频繁检测到其他巴西地区的这些血清型和基因型后，在坎皮纳斯-圣保罗地区的非可分型流感嗜血杆菌 (NTHi) 和侵袭性疾病的菌株有所增加。
