Govindasamy Krpasha, Etter Eric M C, Geertsma Peter, Thompson Peter N
Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa.
Gauteng Department of Agriculture and Rural Development Veterinary Services, Marshalltown, Johannesburg 2000, South Africa.
Pathogens. 2021 Dec 9;10(12):1595. doi: 10.3390/pathogens10121595.
Bovine brucellosis is a zoonotic disease of global public health and economic importance. South Africa has had a national bovine brucellosis eradication scheme since 1979; however, no published report on elimination progress from any province exists. We analysed laboratory test results of all cattle herds participating in the Gauteng Provincial Veterinary Services' eradication scheme between 2013 and 2018. Herd reactor status and within-herd seroprevalence, modelled using mixed-effects logistic and negative binomial regression models, respectively, showed no significant change over the period. However, provincial State Vet Areas, Randfontein (OR = 1.6; 95% CI: 1.2-2.1; < 0.001) and Germiston (OR = 1.9; 95% CI: 1.5-2.5, = 0.008) had higher odds of reactor herds than the Pretoria Area and within-herd prevalence count ratios for these areas were 1.5-fold greater than the Pretoria State Vet Area ( < 0.001). Reactor herds were associated with increased herd size ( < 0.001) and larger herd sizes were associated with lower within-herd prevalence ( < 0.001). Despite no evidence of significant progress toward bovine brucellosis elimination in Gauteng province, variability in bovine brucellosis prevalence between State Vet Areas exists. A public health and farmer-supported strategy of ongoing district-based surveillance and cattle vaccination targeting small- to medium-sized herds combined with compulsory test and slaughter of reactors in larger herds is recommended for the province.
牛布鲁氏菌病是一种对全球公共卫生和经济具有重要意义的人畜共患病。自1979年以来，南非实施了一项全国性的牛布鲁氏菌病根除计划；然而，尚无任何省份发布关于根除进展的报告。我们分析了2013年至2018年期间参与豪登省兽医服务局根除计划的所有牛群的实验室检测结果。分别使用混合效应逻辑回归模型和负二项回归模型对牛群感染状态和群内血清阳性率进行建模，结果显示在此期间没有显著变化。然而，省级国家兽医区，兰德方丹（OR = 1.6；95% CI：1.2 - 2.1；< 0.001）和杰米斯顿（OR = 1.9；95% CI：1.5 - 2.5， = 0.008）的感染牛群几率高于比勒陀利亚地区，且这些地区的群内患病率计数比是比勒陀利亚国家兽医区的1.5倍（< 0.001）。感染牛群与牛群规模增加有关（< 0.001），而较大的牛群规模与较低的群内患病率有关（< 0.001）。尽管没有证据表明豪登省在消除牛布鲁氏菌病方面取得了显著进展，但国家兽医区之间的牛布鲁氏菌病患病率存在差异。建议该省采取一项由公共卫生和农民支持的战略，即持续开展基于地区的监测，并针对中小型牛群进行牛疫苗接种，同时对大型牛群中的感染牛进行强制检测和屠宰。
