Centre for Infectious Diseases, Division of Pathway Medicine, School of Biomedical Science, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 Summerhall Square, Edinburgh, EH9 1QH, UK.
BMC Vet Res. 2011 Oct 18;7:60. doi: 10.1186/1746-6148-7-60.
Human brucellosis has been found to be prevalent in the urban areas of Kampala, the capital city of Uganda. A cross-sectional study was designed to generate precise information on the prevalence of brucellosis in cattle and risk factors for the disease in its urban and peri-urban dairy farming systems.
The adjusted herd prevalence of brucellosis was 6.5% (11/177, 95% CI: 3.6%-10.0%) and the adjusted individual animal prevalence was 5.0% (21/423, 95% CI: 2.7%-9.3%) based on diagnosis using commercial kits of the competitive enzyme-linked immunosorbent assay (CELISA) for Brucella abortus antibodies. Mean within-herd prevalence was found to be 25.9% (95% CI: 9.7%-53.1%) and brucellosis prevalence in an infected herd ranged from 9.1% to 50%. A risk factor could not be identified at the animal level but two risk factors were identified at the herd level: large herd size and history of abortion. The mean number of milking cows in a free-grazing herd (5.0) was significantly larger than a herd with a movement restricted (1.7, p < 0.001).
Vaccination should be targeted at commercial large-scale farms with free-grazing farming to control brucellosis in cattle in and around Kampala city.
在乌干达首都坎帕拉的城市地区发现了人类布鲁氏菌病的流行。本研究设计了一项横断面研究，旨在提供关于牛布鲁氏菌病的流行情况和城市及城郊奶牛养殖系统中该疾病的风险因素的准确信息。
使用商业试剂盒（竞争酶联免疫吸附试验，CELISA）对 Brucella abortus 抗体进行检测，调整后的畜群布鲁氏菌病流行率为 6.5%（11/177，95%置信区间：3.6%-10.0%），调整后的个体动物流行率为 5.0%（21/423，95%置信区间：2.7%-9.3%）。基于商业试剂盒（竞争酶联免疫吸附试验，CELISA）对 Brucella abortus 抗体进行检测，发现畜群内平均流行率为 25.9%（95%置信区间：9.7%-53.1%），感染畜群的布鲁氏菌病流行率范围为 9.1%-50%。在个体动物层面上没有发现风险因素，但在畜群层面上发现了两个风险因素：大畜群规模和流产史。自由放牧畜群的平均挤奶牛数量（5.0）明显大于移动受限畜群（1.7，p<0.001）。
应针对具有自由放牧养殖的商业大规模农场进行疫苗接种，以控制坎帕拉市及其周边地区的牛布鲁氏菌病。
