Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham B15 2GW, UK.
Room D1406 West Block: Queen's Medical Centre, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.
Nutrients. 2021 Dec 8;13(12):4389. doi: 10.3390/nu13124389.
Despite the increasing array of medications available for the treatment of Crohn's disease and a focus on mucosal healing, approximately 35% of patients with Crohn's disease undergo bowel surgery at some stage. The importance of nutritional optimisation before Crohn's surgery is well-highlighted by surgical, nutritional, and gastroenterological societies with the aim of reducing complications and enhancing recovery. Surgical procedures are frequently undertaken when other treatment options have been unsuccessful, and, thus, patients may have lost weight and/or required steroids, and are therefore at higher risk of post-operative complications. EEN is used extensively in the paediatric population to induce remission, but is not routinely used in the induction of remission of adult Crohn's disease or in pre-operative optimisation. Large prospective studies regarding the role of pre-operative EEN are lacking. In this review, we evaluate the current literature on the use of EEN in pre-operative settings and its impact on patient outcomes.
尽管有越来越多的药物可用于治疗克罗恩病,并且关注黏膜愈合,但仍有约 35%的克罗恩病患者在某个阶段需要进行肠道手术。手术、营养和胃肠病学会强调了在克罗恩病手术前进行营养优化的重要性,目的是减少并发症并促进康复。当其他治疗选择无效时,通常会进行手术,因此患者可能已经减轻了体重和/或需要使用类固醇,因此术后并发症的风险更高。EEN 在儿科人群中广泛用于诱导缓解,但在诱导成人克罗恩病缓解或术前优化中并不常规使用。关于术前 EEN 作用的大型前瞻性研究还很缺乏。在这篇综述中,我们评估了术前使用 EEN 的现有文献及其对患者结局的影响。