Nutritional Epidemiology Research Team (EREN), Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inrae U1125, Cnam, Université Sorbonne Paris Nord University, 93017 Bobigny, France.
Service de Gastroentérologie, Hôpital Avicenne, APHP, 93017 Bobigny, France.
Nutrients. 2021 Dec 17;13(12):4513. doi: 10.3390/nu13124513.
(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS). Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study. Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data. Total FODMAP intake (in g/day) was computed using a specific composition table. The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years. FODMAPs accounted for a mean daily intake of 19.4 ± 9.5 g/day. Overall 1295 participants (4.6%) were identified with an IBS. After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, -value: 0.001). IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls. In IBS participants, higher severity was associated with lower intakes.
(1) 背景：特定食物，特别是可发酵的寡糖、二糖和单糖及多元醇（FODMAPs），通常被认为是肠易激综合征（IBS）患者消化道症状的触发因素。我们的目的是在一个大型法国人群队列中研究对照者和 IBS 参与者的 FODMAP 摄入量；(2) 方法：NutriNet-Santé 队列研究的参与者在横断面研究中完成了罗马 IV 和 IBS-SSS 问卷。其中，27949 名符合条件的参与者之前完成了三次 24 小时回忆以及人体测量学、社会人口统计学和生活方式数据的收集。使用特定的成分表计算总 FODMAP 摄入量（g/天）。通过多变量逻辑回归模型评估 FODMAPs 与 IBS 之间的关联；(3) 结果：纳入的参与者主要为女性（75.4%），平均年龄为 43.4±14.1 岁。FODMAPs 的平均日摄入量为 19.4±9.5 g/天。共有 1295 名参与者（4.6%）被诊断为 IBS。在调整了混杂因素后，IBS 参与者的 FODMAPs 摄入量低于非 IBS 参与者（调整后比值比：0.88，95%置信区间：0.82-0.95，P 值：0.001）。IBS 严重程度与更频繁的低 FODMAP 摄入相关（<9 g/天）；(4) 结论：参与者每天平均摄入 19 g FODMAPs，但 IBS 参与者的摄入量略低于对照者。在 IBS 参与者中，较高的严重程度与较低的摄入量相关。
