Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.
Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0595, USA.
Viruses. 2021 Nov 29;13(12):2387. doi: 10.3390/v13122387.
Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). This review focuses on the myriad of mechanisms by which drugs of abuse impact viral replication and disease progression. Virus-drug interactions can accelerate viral disease progression and lead to increased risk of virus transmission.
常见的误用物质，如酒精、可卡因、海洛因、冰毒和阿片类药物，会抑制免疫反应，并可能影响病毒发病机制。近年来，阿片类药物的非法使用引发了几种病毒病原体的爆发，包括人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）。本综述重点介绍了滥用药物影响病毒复制和疾病进展的多种机制。病毒-药物相互作用可加速病毒疾病的进展，并导致病毒传播风险增加。
