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制备的油/聚乙烯吡咯烷酮/金聚合物生物纳米复合膜的免疫调节和抗原生动物潜力

Immunomodulatory and Antiprotozoal Potential of Fabricated Oil/Polyvinylpyrrolidone/Au Polymeric Bionanocomposite Film.

作者信息

Alarfaj Nawal A, Amina Musarat, Al Musayeib Nawal M, El-Tohamy Maha F, Al-Hamoud Gadah A

机构信息

Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh 11451, Saudi Arabia.

出版信息

Polymers (Basel). 2021 Dec 10;13(24):4321. doi: 10.3390/polym13244321.

DOI:10.3390/polym13244321
PMID:34960872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8709204/
Abstract

A unique morphological oil/polyvinylpyrrolidone/gold polymeric bionanocomposite film was synthesized using the oil dispersed in a polymeric polyvinylpyrrolidone (PVP) matrix and decorated with gold nanoparticles (AuNPs). The chemical and physical characteristics as well as the thermal stability of the synthesized bionanocomposite film were investigated using various spectroscopic and microscopic techniques. The microscopic analysis confirmed well dispersed AuNPs in the PVP- oil matrix with particle size of 100 nm. Immunomodulatory and antiprotozoal potentials of the suggested bionanocomposite film were evaluated for lipopolysaccharide-induced BV-2 microglia and against , promastigotes and epimastigotes, respectively. The results exerted outstanding reduction of inflammatory cytokines' (IL-6 and TNFα) secretions after pretreatment of bionanocomposite. The bionanocomposite exhibited large inhibitory effects on certain cell signaling components that are related to the activation of expression of proinflammatory cytokines. Additionally, AuNPs and bionanocomposite exhibited excellent growth inhibition of and promastigotes with IC (1.71 ± 1.49, 1.68 ± 0.75) and (1.12 ± 1.10, 1.42 ± 0.69), respectively. However, the nanomaterials showed moderate activity towards . All outcomes indicated promising immunomodulatory, antiprotozoal, and photocatalytic potentials for the synthesized oil/PVP/Au polymeric bionanocomposite.

摘要

通过将油分散在聚合物聚乙烯吡咯烷酮（PVP）基质中并装饰金纳米颗粒（AuNPs），合成了一种独特形态的油/聚乙烯吡咯烷酮/金聚合物生物纳米复合薄膜。使用各种光谱和显微镜技术研究了合成的生物纳米复合薄膜的化学和物理特性以及热稳定性。微观分析证实，AuNPs在PVP-油基质中分散良好，粒径为100nm。分别评估了所建议的生物纳米复合薄膜对脂多糖诱导的BV-2小胶质细胞以及对前鞭毛体和上鞭毛体的免疫调节和抗原生动物潜力。结果表明，生物纳米复合材料预处理后，炎性细胞因子（IL-6和TNFα）的分泌显著减少。该生物纳米复合材料对某些与促炎细胞因子表达激活相关的细胞信号成分表现出较大的抑制作用。此外，AuNPs和生物纳米复合材料对前鞭毛体和上鞭毛体均表现出优异的生长抑制作用，IC50分别为（1.71±1.49，1.68±0.75）和（1.12±1.10，1.42±0.69）。然而，这些纳米材料对[此处原文缺失相关内容]表现出中等活性。所有结果表明，合成的油/PVP/Au聚合物生物纳米复合材料具有良好的免疫调节、抗原生动物和光催化潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a6/8709204/678419d09908/polymers-13-04321-g013.jpg
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