Zahariev Nikolay, Marudova Maria, Milenkova Sophia, Uzunova Yordanka, Pilicheva Bissera
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Research Institute, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Polymers (Basel). 2021 Dec 13;13(24):4357. doi: 10.3390/polym13244357.
The aim of the present work was to optimize the process parameters of the nano spray drying technique for the formulation of benzydamine-loaded casein nanoparticles and to investigate the effect of some process variables on the structural and morphological characteristics and release behavior. The obtained particles were characterized in terms of particle size and size distribution, surface morphology, production yield and encapsulation efficiency, drug-polymer compatibility, etc., using dynamic light scattering, scanning electron microscopy, differential scanning calorimetry, and Fourier transformed infrared spectroscopy. Production yields of the blank nanoparticles were significantly influenced by the concentration of both casein and the crosslinking agent. The formulated drug-loaded nanoparticles had an average particle size of 135.9 nm to 994.2 nm. Drug loading varied from 16.02% to 57.41% and the encapsulation efficiency was in the range 34.61% to 78.82%. Our study has demonstrated that all the investigated parameters depended greatly on the polymer/drug ratio and the drug release study confirmed the feasibility of the developed nanocarriers for prolonged delivery of benzydamine.
本研究的目的是优化纳米喷雾干燥技术的工艺参数，以制备负载苄达明的酪蛋白纳米颗粒，并研究一些工艺变量对其结构、形态特征及释放行为的影响。使用动态光散射、扫描电子显微镜、差示扫描量热法和傅里叶变换红外光谱等手段，对所得颗粒的粒径及粒径分布、表面形态、产率、包封率、药物-聚合物相容性等进行了表征。空白纳米颗粒的产率受酪蛋白和交联剂浓度的显著影响。所制备的载药纳米颗粒的平均粒径为135.9 nm至994.2 nm。载药量在16.02%至57.41%之间，包封率在34.61%至78.82%之间。我们的研究表明，所有研究参数在很大程度上取决于聚合物/药物比例，药物释放研究证实了所开发的纳米载体用于苄达明长效递送的可行性。
