Kasting N W, Wilkinson M F
Biol Neonate. 1987;51(5):249-54. doi: 10.1159/000242660.
These experiments sought to determine the role of arginine vasopressin (AVP) in the inability of newborns to produce a fever. Our data demonstrate that the AVP analog, [1-(beta-mercapto-beta,beta-cyclopentamethylene propionic acid)-2-(O-methyl) tyrosine]arginine vasopressin (M-AVP), administered centrally to adult rats, prevented the antipyretic action of centrally injected AVP. Behaviorally thermoregulating 3-day-old rat pups failed to respond to endoxin with a fever, similar to neonates of other species, but when central AVP antipyretic receptors were blocked by pretreatment with M-AVP, the pups were able to raise their body temperature to febrile levels. The antipyretic drug, indomethacin, prevented these fevers. We conclude that endogenous AVP is a physiologically important antipyretic substance in the brain of the newborn rat.
这些实验旨在确定精氨酸加压素（AVP）在新生儿无法发热中所起的作用。我们的数据表明，向成年大鼠中枢给予AVP类似物[1-（β-巯基-β，β-环戊亚甲基丙酸）-2-（O-甲基）酪氨酸]精氨酸加压素（M-AVP），可阻止中枢注射AVP的解热作用。与其他物种的新生儿相似，行为性体温调节的3日龄幼鼠对内毒素不产生发热反应，但当用M-AVP预处理阻断中枢AVP解热受体时，幼鼠能够将体温升高至发热水平。解热药物吲哚美辛可预防这些发热。我们得出结论，内源性AVP是新生大鼠大脑中一种生理上重要的解热物质。
