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MVE-II用于转移性恶性黑色素瘤的II期试验。

Phase II trial of MVE-II in metastatic malignant melanoma.

作者信息

Rinehart J, LaForge J, Gochnour D, Neidhart J

出版信息

Cancer Immunol Immunother. 1987;24(3):244-6. doi: 10.1007/BF00205637.

DOI:10.1007/BF00205637
PMID:3496153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038851/
Abstract

MVE-II, a low molecular weight fraction of pyran copolymer was utilized in a Phase II trial in patients with metastatic malignant melanoma. A total of 15 patients were investigated and no clinical responses or immunologic responses were observed. We concluded that MVE-II is not an active agent in malignant melanoma.

摘要

MVE-II，一种吡喃共聚物的低分子量组分，被用于转移性恶性黑色素瘤患者的II期试验。共对15名患者进行了研究，未观察到临床反应或免疫反应。我们得出结论，MVE-II在恶性黑色素瘤中不是一种活性药物。

相似文献

1
Phase II trial of MVE-II in metastatic malignant melanoma.MVE-II用于转移性恶性黑色素瘤的II期试验。
Cancer Immunol Immunother. 1987;24(3):244-6. doi: 10.1007/BF00205637.
2
Evaluation of the immunological and toxicological properties of MVE-2 in phase I trials.MVE - 2在I期试验中的免疫学和毒理学特性评估。
Cancer Res. 1983 May;43(5):2358-62.
3
Phase I study of MVE-2 evaluating toxicity and biologic response modification capability.评估MVE-2毒性及生物反应修饰能力的I期研究。
Cancer Immunol Immunother. 1986;22(1):68-71. doi: 10.1007/BF00205719.
4
Pyran (MVE-5) reverses the inhibition of macrophage receptors for cytophilic antibody induced by soluble immune complexes.吡喃（MVE - 5）可逆转可溶性免疫复合物对巨噬细胞嗜细胞抗体受体的抑制作用。
J Biol Response Mod. 1983;2(1):67-80.
5
Responsiveness of the Madison 109 lung carcinoma to maleic vinyl ether copolymer.麦迪逊109肺癌对马来酸乙烯基醚共聚物的反应性
J Immunopharmacol. 1983;5(1-2):31-47. doi: 10.3109/08923978309026441.
6
Therapy of artificial and spontaneous metastases of murine tumors with maleic anhydride-divinyl ether-2.用马来酸酐-二乙烯基醚-2治疗小鼠肿瘤的人工转移和自发转移
Cancer Res. 1981 Jun;41(6):2378-85.
7
Immunomodulation and antitumor effects of MVE-2 in mice.MVE-2对小鼠的免疫调节及抗肿瘤作用
J Biol Response Mod. 1984 Dec;3(6):634-52.
8
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Clinical pharmacology of the biological response modifier maleic anhydride divinyl ether copolymer (MVE-2).
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Dis Colon Rectum. 1985 Apr;28(4):217-21. doi: 10.1007/BF02554033.

本文引用的文献

1
The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance.合成聚阴离子吡喃共聚物（迪维马，MVE，46015）以及杂环双二乙氨基乙基芴酮衍生物、泰洛龙及其同系物的生物活性：这些作为宿主抵抗力调节剂的药物的临床和实验室效应。
Pharmacol Ther. 1981;15(1):1-44. doi: 10.1016/0163-7258(81)90014-0.
2
Evaluation of the immunological and toxicological properties of MVE-2 in phase I trials.MVE - 2在I期试验中的免疫学和毒理学特性评估。
Cancer Res. 1983 May;43(5):2358-62.
3
Effect of interferon inducers and interferon on bacterial infections.干扰素诱导剂及干扰素对细菌感染的作用。
Antimicrob Agents Chemother. 1972 Jan;1(1):80-1. doi: 10.1128/AAC.1.1.80.
4
Combined drug and immunostimulation therapy against a syngeneic murine leukemia.联合药物与免疫刺激疗法对抗同基因小鼠白血病
J Natl Cancer Inst. 1974 Feb;52(2):463-8. doi: 10.1093/jnci/52.2.463.
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Divinyl ether-maleic anhydride (pyran) copolymer used to demonstrate the effect of molecular weight on biological activity.
Nature. 1973 Nov 16;246(5429):160-2. doi: 10.1038/246160a0.
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The routinization of intraperitoneal (intracavitary) chemotherapy and immunotherapy.
Cancer Invest. 1986;4(1):29-42. doi: 10.3109/07357908609039825.
7
Effect of maleic anhydride-divinyl ether copolymers on experimental M109 metastases and macrophage tumoricidal function.
Cancer Treat Rep. 1978 Nov;62(11):1817-22.
8
Response of murine leukemia to combined BCNU-maleic anhydride-vinyl ether (MVE) adjuvant therapy and correlation with macrophage activation by MVE in the in vitro growth inhibition assay.小鼠白血病对卡莫司汀-马来酸酐-乙烯基醚（MVE）联合辅助治疗的反应以及在体外生长抑制试验中与MVE激活巨噬细胞的相关性。
Cancer Treat Rep. 1978 Nov;62(11):1807-16.
9
Relationship of molecular weight to antiviral and antitumor activities and toxic effects of maleic anhydride-divinyl ether (MVE) polyanions.
Cancer Treat Rep. 1978 Nov;62(11):1797-803.