Spaarne Academy, Spaarne Gasthuis, Hoofddorp and Haarlem, Netherlands; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Centre Utrecht, Utrecht, Netherlands.
Spaarne Academy, Spaarne Gasthuis, Hoofddorp and Haarlem, Netherlands; Department of Paediatrics, Spaarne Gasthuis, Hoofddorp and Haarlem, Netherlands.
Vaccine. 2022 Jan 24;40(3):408-413. doi: 10.1016/j.vaccine.2021.12.013. Epub 2021 Dec 24.
Pneumococcal conjugate vaccines reduce pneumococcal colonization via serotype-specific immunoglobulin G (IgG) at mucosal surfaces. The infant immunization schedule with the ten-valent pneumococcal conjugate vaccine (PCV10) changed from a 3 + 1 schedule (2-3-4-11 months) to a 2 + 1 schedule (2-4-11 months) in The Netherlands in 2013. We compared anti-pneumococcal IgG concentrations in saliva between the schedules. IgG was measured using a fluorescent bead-based multiplex immunoassay at the ages of 6 (post-primary) and 12 (post-booster) months in 51 infants receiving the 3 + 1 schedule and 68 infants receiving the 2 + 1 schedule. Post-primary IgG geometric mean concentrations (GMCs) were comparable between schedules for all vaccine serotypes. Post-booster IgG GMCs were significantly lower after the 2 + 1 schedule for serotypes 4 (p = 0.035), 7F (p = 0.048) and 23F (p = 0.0056). This study shows small differences in mucosal IgG responses between a 3 + 1 and a 2 + 1 PCV10 schedule. Future studies should establish correlates of protection against pneumococcal colonization for mucosal antibodies.
肺炎球菌结合疫苗通过黏膜表面的血清型特异性免疫球蛋白 G（IgG）减少肺炎球菌定植。2013 年，荷兰将十价肺炎球菌结合疫苗（PCV10）的婴儿免疫接种计划从 3+1 方案（2-3-4-11 个月）改为 2+1 方案（2-4-11 个月）。我们比较了两种方案中唾液中的抗肺炎球菌 IgG 浓度。在 51 名接受 3+1 方案和 68 名接受 2+1 方案的婴儿中，在 6 个月（初免后）和 12 个月（加强后）龄时，使用荧光珠基多重免疫分析测定 IgG。对于所有疫苗血清型，两种方案的初免后 IgG 几何平均浓度（GMC）相似。在 2+1 方案后，血清型 4（p=0.035）、7F（p=0.048）和 23F（p=0.0056）的 IgG 增强后 GMC 显著降低。本研究表明，3+1 和 2+1 PCV10 方案之间黏膜 IgG 反应存在微小差异。未来的研究应该确定针对黏膜抗体的肺炎球菌定植保护相关性。
